Evidence map›Paper›PMID 38383060›Full record

ArticleBioinformatics (Oxford, England)2024

preon: Fast and accurate entity normalization for drug names and cancer types in precision oncology.

Arik Ermshaus, Michael Piechotta, Gina Rüter, Ulrich Keilholz, Ulf Leser, Manuela Benary

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arik ErmshausInstitute for Computer Science, Humboldt-Universität zu Berlin, Berlin 10099, Germany.
Michael PiechottaInstitute for Computer Science, Humboldt-Universität zu Berlin, Berlin 10099, Germany.
Gina RüterCharite Comprehensive Cancer Center, Charite-Universitätsmedizin Berlin, Berlin 10115, Germany.
Ulrich KeilholzCharite Comprehensive Cancer Center, Charite-Universitätsmedizin Berlin, Berlin 10115, Germany.
Ulf LeserInstitute for Computer Science, Humboldt-Universität zu Berlin, Berlin 10099, Germany.
Manuela BenaryCharite Comprehensive Cancer Center, Charite-Universitätsmedizin Berlin, Berlin 10115, Germany.ORCID 0000-0002-3067-2030

Funding

European Fund for Regional DevelopmentFederal State of BerlinGerman Federal Ministry of Education and Research 031L0023Innovation Committee of the Federal Joint Committee of Germany
6 · The paper itself

Abstract

motivationIn precision oncology (PO), clinicians aim to find the best treatment for any patient based on their molecular characterization. A major bottleneck is the manual annotation and evaluation of individual variants, for which usually a range of knowledge bases are screened. To incorporate and integrate the vast information of different databases, fast and accurate methods for harmonizing databases with different types of information are necessary. An essential step for harmonization in PO includes the normalization of tumor entities as well as therapy options for patients. SUMMARY: preon is a fast and accurate library for the normalization of drug names and cancer types in large-scale data integration. AVAILABILITY AND IMPLEMENTATION: preon is implemented in Python and freely available via the PyPI repository. Source code and the data underlying this article are available in GitHub at https://github.com/ermshaua/preon/.

Indexed as

NeoplasmsDatabases, FactualHumansMedical OncologyPrecision MedicineSoftware

Identifiers

PMID38383060
PMCPMC10918631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.