Evidence map›Paper›PMID 38383048›Full record

ArticleBioinformatics (Oxford, England)2024

LAVASET: Latent Variable Stochastic Ensemble of Trees. An ensemble method for correlated datasets with spatial, spectral, and temporal dependencies.

Melpomeni Kasapi, Kexin Xu, Timothy M D Ebbels, Declan P O'Regan, James S Ware, Joram M Posma

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Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Melpomeni KasapiSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0003-1854-1799
Kexin XuSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Timothy M D EbbelsSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0002-3372-8423
Declan P O'ReganFaculty of Medicine, National Heart & Lung Institute, Imperial College London, London W12 0NN, United Kingdom.
James S WareFaculty of Medicine, National Heart & Lung Institute, Imperial College London, London W12 0NN, United Kingdom.
Joram M PosmaSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0002-4971-9003

Funding

Biotechnology and Biological Sciences Research CouncilBritish Heart Foundation RE/18/4/34215British Heart Foundation RG/19/6/34387Medical Research Council MC_UP_1102/20Medical Research Council MC_UP_1605/13Medical Research Council MR/S004033/1Wellcome Trust 220119
6 · The paper itself

Abstract

motivationRandom forests (RFs) can deal with a large number of variables, achieve reasonable prediction scores, and yield highly interpretable feature importance values. As such, RFs are appropriate models for feature selection and further dimension reduction. However, RFs are often not appropriate for correlated datasets due to their mode of selecting individual features for splitting. Addressing correlation relationships in high-dimensional datasets is imperative for reducing the number of variables that are assigned high importance, hence making the dimension reduction most efficient. Here, we propose the LAtent VAriable Stochastic Ensemble of Trees (LAVASET) method that derives latent variables based on the distance characteristics of each feature and aims to incorporate the correlation factor in the splitting step.

resultsWithout compromising on performance in the majority of examples, LAVASET outperforms RF by accurately determining feature importance across all correlated variables and ensuring proper distribution of importance values. LAVASET yields mostly non-inferior prediction accuracies to traditional RFs when tested in simulated and real 1D datasets, as well as more complex and high-dimensional 3D datatypes. Unlike traditional RFs, LAVASET is unaffected by single 'important' noisy features (false positives), as it considers the local neighbourhood. LAVASET, therefore, highlights neighbourhoods of features, reflecting real signals that collectively impact the model's predictive ability. AVAILABILITY AND IMPLEMENTATION: LAVASET is freely available as a standalone package from https://github.com/melkasapi/LAVASET.

Identifiers

PMID38383048
PMCPMC11212485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.