ArticleBMJ open2024
Operation-specific risk of postoperative nausea: a cross-sectional study comparing 72 procedures.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Randomized Multicenter Trial of Acupressure in Patients Undergoing Moderately to Highly Emetogenic Chemotherapy.Clinical journal of oncology nursing · 2025Trial
- The OPIAID Zone Tool (Version 0.5) as a Composite Outcome for Postoperative Pain Management Quality.Acta anaesthesiologica Scandinavica · 2026Observational
- The Use of Intravenous Clonidine in Postoperative Pain Management: A Scoping Review.Acta anaesthesiologica Scandinavica · 2026Article
- Article
- Perioperative Anesthesia Strategies for the Prevention of Postoperative Nausea and Vomiting Within Enhanced Recovery After Surgery Pathways: A Clinical Narrative Review.Journal of clinical medicine · 2026Review
- Association Between Digit Ratio and Postoperative Nausea and Vomiting: A Single-Center Prospective Cohort Study.Anesthesiology research and practice · 2026Article
- Early Postoperative Nausea and Vomiting After Bariatric Surgery: A Study of 8426 Patients from the Swedish Perioperative Registry (SPOR).Obesity surgery · 2025Observational
- Clinical practice guidelines for the prevention and management of postoperative nausea and vomiting (2025 edition).Journal of anesthesia and translational medicine · 2025Review
- Incidence and risk factor evaluation for postoperative nausea and vomiting in cesarean section under general anesthesia compared to the gynecologic surgery: A retrospective study.The journal of obstetrics and gynaecology research · 2025Article
- Effects of dexmedetomidine and sevoflurane on optic nerve sheath diameter and postoperative nausea and vomiting in patients undergoing microvascular decompression: a retrospective cohort study.BMC anesthesiology · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
objectivesDetermination of the procedure-specific, risk-adjusted probability of nausea.
designCross-sectional analysis of clinical and patient-reported outcome data. We used a logistic regression model with type of operation, age, sex, preoperative opioids, antiemetic prophylaxis, regional anaesthesia, and perioperative opioids as predictors of postoperative nausea.
settingData from 152 German and Austrian hospitals collected in the Quality Improvement in Postoperative Pain Treatment (QUIPS) registry from 2013 to 2022. Participants completed a validated outcome questionnaire on the first postoperative day. Operations were categorised into groups of at least 100 cases.
participantsWe included 78 231 of the 293 947 participants from the QUIPS registry. They were 18 years or older, willing and able to participate and could be assigned to exactly one operation group.
main outcome measuresAdjusted absolute risk of nausea on the first postoperative day for 72 types of operation.
resultsThe adjusted absolute risk of nausea ranged from 6.2% to 36.2% depending on the type of operation. The highest risks were found for laparoscopic bariatric operations (36.2%), open hysterectomy (30.4%), enterostoma relocation (29.8%), open radical prostatectomy (28.8%), laparoscopic colon resection (28.6%) and open sigmoidectomy (28%). In a logistic regression model, male sex (OR: 0.39, 95% CI 0.37 to 0.41, p<0.0001), perioperative nausea and vomiting prophylaxis (0.73, 0.7 to 0.76, p<0.0001), intraoperative regional anaesthesia (0.88, 0.83 to 0.93, p<0.0001) and preoperative opioids for chronic pain (0.74, 0.68 to 0.81, p<0.0001) reduced the risk of nausea. Perioperative opioid use increased the OR up to 2.38 (2.17 to 2.61, p<0.0001).
conclusionsThe risk of postoperative nausea varies considerably between surgical procedures. Patients undergoing certain types of operation should receive special attention and targeted prevention strategies. Adding these findings to known predictive tools may raise awareness of the still unacceptably high incidence of nausea in certain patient groups. This may help to further reduce the prevalence of nausea. TRIAL REGISTRATION NUMBER: DRKS00006153; German Clinical Trials Register; https://drks.de/search/de/trial/DRKS00006153.
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