ArticleJournal of affective disorders2024
Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data.
Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Direct and indirect associations linking COVID-19 severity to internalizing disorders and symptoms among participants in New Haven, CT.Journal of affective disorders · 2026Article
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6 authors at 2 institutions in 2 countries.
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Abstract
backgroundThere is still a limited understanding of the dynamics contributing to the comorbidity of COVID-19 and anxiety outcomes.
methodsTo dissect the pleiotropic mechanisms contributing to COVID-19/anxiety comorbidity, we used genome-wide data from UK Biobank (up to 420,531 participants), FinnGen Project (up to 329,077 participants), Million Veteran Program (175,163 participants), and COVID-19 Host Genetics Initiative (up to 122,616 cases and 2,475,240 controls). Specifically, we assessed global and local genetic correlation and genetically inferred effects linking COVID-19 outcomes (infection, hospitalization, and severe respiratory symptoms) to anxiety disorders and symptoms.
resultsWe observed a strong genetic correlation of anxiety disorder with COVID-19 positive status (rg = 0.35, p = 2×10
conclusionsThis study provided insights into the pleiotropic mechanisms linking COVID-19 and anxiety outcomes, suggesting differences between dynamics related to anxiety disorders and those related to anxiety symptoms.
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