Evidence map›Paper›PMID 38382190›Full record

ArticleAmerican journal of veterinary research2024

Neurofilament light chain concentration does not correlate with disease status in Labrador Retrievers affected with idiopathic laryngeal paralysis.

Jacquelyn H Perino, Margaret Patterson, Mehdi Momen, Mina Borisova, Amanda Heslegrave, Henrik Zetterberg, Jordan Gruel, Emily E Binversie, Ryan S Anderson, Helena Rylander and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Jacquelyn H PerinoComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Margaret PattersonComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Mehdi MomenComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Mina BorisovaDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Amanda HeslegraveDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Henrik ZetterbergDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Jordan GruelComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Emily E BinversieComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Ryan S AndersonComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Helena RylanderDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Starr CameronDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Benjamin MirandaComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Gabi ConidiComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
John SvarenDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Susannah J SampleComparative Genetic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
University of Wisconsin–Madison · USUniversity College London · GBSahlgrenska University Hospital · SE

Funding

Comparative Biomedical Sciences Training ProgramT32OD010423 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Marulasiddappa Suresh · 2012 to 2026
$5.0M
Genotypic and neuropathologic dissection of acquired periperal neuropathy in a canine modelK01OD019743 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI SAMPLE, SUSANNAH · 2015 to 2019
$722k
NIH HHS K01 OD019743NIH HHS T32 OD010423
6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate whether plasma neurofilament light chain (pNfL) concentration was altered in Labrador Retrievers with idiopathic laryngeal paralysis (ILP) compared to a control population. A secondary aim was to investigate relationships between age, height, weight, and body mass index in the populations studied. ANIMALS: 123 dogs: 62 purebred Labrador Retrievers with ILP (ILP Cases) and 61 age-matched healthy medium- to large-breed dogs (Controls).

methodsDogs, recruited from August 1, 2016, to March 1, 2022, were categorized as case or control based on a combination of physical exam, neurologic exam, and history. Blood plasma was collected, and pNfL concentration was measured. pNfL concentrations were compared between ILP Cases and Controls. Covariables including age, height, and weight were collected. Relationships between pNfL and covariables were analyzed within and between groups. In dogs where 2 plasma samples were available from differing time points, pNfL concentrations were measured to evaluate alterations over time.

resultsNo significant difference in pNfL concentration was found between ILP Cases and Control (P = .36). pNfL concentrations had moderate negative correlations with weight and height in the Control group; other variables did not correlate with pNfL concentrations in ILP Case or Control groups. pNfL concentrations do not correlate with ILP disease status or duration in Labrador Retrievers. CLINICAL RELEVANCE: There is no evidence that pNfL levels are altered due to ILP disease duration or progression when compared with healthy controls. When evaluating pNfL concentrations in the dog, weight and height should be considered.

Indexed as

Dog DiseasesVocal Cord ParalysisAnimalsDogsIntermediate Filamentsaxonopathydogneurofilament light chainneuropathyperipheral neuropathy

Identifiers

PMID38382190
PMCPMC11059241
OpenAlexW4391956409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.