Evidence map›Paper›PMID 38381789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Diverse roles of pontine NPS-expressing neurons in sleep regulation.

Lijuan Xing, Xianlin Zou, Chen Yin, John M Webb, Guangsen Shi, Louis J Ptáček, Ying-Hui Fu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease.Diabetes/metabolism research and reviews · 2025
    Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lijuan XingDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
Xianlin ZouDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
Chen YinDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
John M WebbDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
Guangsen ShiZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Louis J PtáčekDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
Ying-Hui FuDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143.
University of California, San Francisco · USShanghai Institute of Materia Medica · CN

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
Probing genetics and biology of human sleep homeostasisR01NS117929 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PTACEK, LOUIS J. · 2021 to 2025
$3.3M
Investigating the neurocircuitry of sleep duration regulationR01NS104782 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2018 to 2022
$3.0M
Investigating Genetics of Human Natural Short SleepersR01NS072360 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2011 to 2015
$2.2M
NIDDK NIH HHS P30 DK063720NIH HHS NS072360 and NS104782NIH HHS NS117929NINDS NIH HHS R01 NS072360NINDS NIH HHS R01 NS104782NINDS NIH HHS R01 NS117929
6 · The paper itself

Abstract

Neuropeptide S (NPS) was postulated to be a wake-promoting neuropeptide with unknown mechanism, and a mutation in its receptor (NPSR1) causes the short sleep duration trait in humans. We investigated the role of different NPS

Indexed as

NeuropeptidesSleepHumansLocus CoeruleusNeuronsPonsReceptors, G-Protein-CoupledNeuropeptidesNPSR1 protein, humanReceptors, G-Protein-Coupledcentral gray of the ponsneural circuitryNPSparabrachial nucleussleep

Identifiers

PMID38381789
PMCPMC10907243
OpenAlexW4391992114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.