Evidence map›Paper›PMID 38381784›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Lutetium texaphyrin: A photocatalyst that triggers pyroptosis via biomolecular photoredox catalysis.

Yunjie Xu, Calvin V Chau, Jieun Lee, Adam C Sedgwick, Le Yu, Mingle Li, Xiaojun Peng, Jong Seung Kim, Jonathan L Sessler

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Yunjie XuDepartment of Chemistry, Korea University, Seoul 02841, Korea.ORCID 0000-0003-0730-8473
Calvin V ChauDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712-1224.
Jieun LeeDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Adam C SedgwickDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712-1224.
Le YuDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Mingle LiCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-0384-9128
Xiaojun PengCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Jong Seung KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.ORCID 0000-0003-3477-1172
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712-1224.ORCID 0000-0002-9576-1325
Korea University · KRThe University of Texas at Austin · USShenzhen University · CN

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
NCI NIH HHS R01 CA068682
6 · The paper itself

Abstract

Photon-controlled pyroptosis activation (PhotoPyro) is a promising technique for cancer immunotherapy due to its noninvasive nature, precise control, and ease of operation. Here, we report that biomolecular photoredox catalysis in cells might be an important mechanism underlying PhotoPyro. Our findings reveal that the photocatalyst lutetium texaphyrin (

Indexed as

MetalloporphyrinsPyroptosisReactive Oxygen SpeciesMetalloporphyrinsmotexafin lutetiumReactive Oxygen SpeciesNAD(P)HNIR photocatalystPhotoPyrophotoredox catalysispyroptosis

Identifiers

PMID38381784
PMCPMC10907263
OpenAlexW4392018214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.