Evidence map›Paper›PMID 38381763›Full record

ArticlePloS one2024

Loneliness and fearfulness are associated with non-fatal drug overdose among people who inject drugs.

Oluwaseun Falade-Nwulia, Kathleen Ward, Karla D Wagner, Hamidreza Karimi-Sari, Jeffrey Hsu, Mark Sulkowski, Carl Latkin, Evaristus Nwulia

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The relationship between low social/emotional support and health care affordability among rural and urban residents.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oluwaseun Falade-NwuliaDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0003-2321-2295
Kathleen WardDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0003-4552-2585
Karla D WagnerSchool of Public Health, University of Nevada, Reno, NV, United States of America.ORCID 0000-0002-8614-2004
Hamidreza Karimi-SariDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0002-6827-9496
Jeffrey HsuDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Mark SulkowskiDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Carl LatkinDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Evaristus NwuliaDepartment of Psychiatry, Howard University, Washington, DC, United States of America.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Management/Hepatitis C/HIV-infected and Uninfected IDU'sR01DA016065 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2003 to 2018
$8.0M
Ending the HIV Epidemic: Peer-supported collaborative care for mental health and substance use disorder care integration into HIV care settingsR01DA052297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI FALADE-NWULIA, OLUWASEUN · 2020 to 2024
$3.5M
Patient Oriented Research in Hepatitis C-infected Injection Drug UsersK24DA034621 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2012 to 2022
$1.2M
The impact of social networks on hepatitis C transmission and care access in people who inject drugsK23DA041294 · NIDA · JOHNS HOPKINS UNIVERSITY · PI FALADE-NWULIA, OLUWASEUN · 2016 to 2020
$924k
NIAID NIH HHS P30 AI094189NIDA NIH HHS K23 DA041294NIDA NIH HHS K24 DA034621NIDA NIH HHS R01 DA016065NIDA NIH HHS R01 DA052297
6 · The paper itself

Abstract

backgroundPeople who inject drugs (PWID) experience high rates of drug overdose death with the risk of mortality increasing after each non-fatal event. Racial differences exist in drug overdose rates, with higher rates among Black people who use drugs. Psychological factors may predict drug overdose.

methodsCross-sectional data from a survey administered to PWID in Baltimore, MD enrolled in a social network-based intervention were analyzed. Linear regression methods with generalized estimating equations were used to analyze data from indexes and network members to assess for psychological factors significantly associated with self-reported number of lifetime drug overdoses. Factors associated with number of overdoses were assessed separately by race.

resultsAmong 111 PWID enrolled between January 2018 and January 2019, 25.2% were female, 65.7% were Black, 98.2% reported use of substances in addition to opioids, and the mean age was 49.0 ± 8.3 years. Seventy-five individuals (67.6%) had a history of any overdose with a mean of 5.0 ± 9.7 lifetime overdoses reported. Reports of feeling fearful (β = 9.74, P = 0.001) or feeling lonely all of the time (β = 5.62, P = 0.033) were independently associated with number of drug overdoses. In analyses disaggregated by race, only the most severe degree of fearfulness or loneliness was associated with overdose among Black participants, whereas among White participants, any degree of fearfulness or loneliness was associated with overdose.

conclusionsIn this study of PWID loneliness and fearfulness were significantly related to the number of reported overdose events. These factors could be targeted in future interventions.

Indexed as

Drug OverdoseDrug UsersSubstance Abuse, IntravenousAdultCross-Sectional StudiesFemaleHumansLonelinessMaleMiddle Aged

Identifiers

PMID38381763
PMCPMC10880973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.