Evidence map›Paper›PMID 38381708›Full record

ArticlePloS one2024

Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation.

Jon Mercader Ruiz, Maider Beitia, Diego Delgado, Pello Sánchez, Miren Begoña Sánchez, Jaime Oraa, Fernando Benito-Lopez, Lourdes Basabe-Desmonts, Mikel Sánchez

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jon Mercader RuizArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Maider BeitiaAdvanced Biological Therapy Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Diego DelgadoAdvanced Biological Therapy Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Pello SánchezArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Miren Begoña SánchezArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Jaime OraaArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.
Fernando Benito-LopezMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain.
Lourdes Basabe-DesmontsMicrofluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Mikel SánchezArthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.ORCID 0000-0001-9992-6927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-Rich Plasma, also known as PRP, is an autologous biologic product used in medicine as a treatment for tissue repair. Nowadays, the majority of PRP obtention methods enrich only platelets, not considering extraplatelet biomolecules, which take part in several cell processes. In the present work, a novel PRP preparation method was developed to obtain a PRP rich in both platelet and plasma extraplatelet molecules. The method is based on the evaporation of the water of the plasma using a rotary evaporator. With this new methodology an increase in plasmatic growth factors and, as a consequence, a better dermal fibroblast cell viability was achieved, compared to a standard PRP formulation. This novel PRP product obtained with this new methodology showed promising results in vitro as an improved PRP treatment in future application.

Indexed as

Intercellular Signaling Peptides and ProteinsPlatelet-Rich PlasmaBlood PlateletsWound HealingIntercellular Signaling Peptides and Proteins

Identifiers

PMID38381708
PMCPMC10880971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.