Evidence map›Paper›PMID 38381583›Full record

SynthesisStem cells translational medicine2024

Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis.

Christine Hum, Usama Tahir, Shirley H J Mei, Josee Champagne, Dean A Fergusson, Manoj Lalu, Duncan J Stewart, Keith Walley, John Marshall, Claudia C Dos Santos and 4 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stem cells translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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  11. Cell Therapies for Acute Radiation Syndrome.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Christine HumClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0009-0004-8695-9884
Usama TahirDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Shirley H J MeiRegenerative Medicine Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Josee ChampagneClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Dean A FergussonClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Manoj LaluClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Duncan J StewartRegenerative Medicine Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Keith WalleyDepartment of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
John MarshallDepartment of Surgery (Critical Care), University of Toronto, Toronto, ON, Canada.
Claudia C Dos SantosKeenan Research Centre for Biomedical Science and Interdepartmental Division of Critical Care, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Brent W WinstonDepartment of Critical Care Medicine, University of Calgary, Calgary, AB, Canada.
Asher A MendelsonSection of Critical Care Medicine, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Chintan DaveDivision of Critical Care Medicine, Department of Medicine, Western University, London, ON, Canada.ORCID 0000-0003-4371-7645
Lauralyn McIntyreClinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
University of Ottawa · CAOttawa Hospital · CAUniversity of British Columbia · CASt. Michael's Hospital · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Toronto · CAWestern University · CA

Funding

Stem Cell Network
6 · The paper itself

Abstract

backgroundIn preclinical studies, mesenchymal stromal cells (MSCs), including umbilical cord-derived MSCs (UC-MSCs), demonstrate the ability to modulate numerous pathophysiological processes related to sepsis; however, a systematic synthesis of the literature is needed to assess the efficacy of UC-MSCs for treating sepsis.

objectiveTo examine the effects of UC-MSCs on overall mortality (primary outcome) as well as on organ dysfunction, coagulopathy, endothelial permeability, pathogen clearance, and systemic inflammation (secondary outcomes) at prespecified time intervals in preclinical models of sepsis.

methodsA systematic search was conducted on Embase, Ovid MEDLINE, and Web of Science up to June 20, 2023. Preclinical controlled studies using in vivo sepsis models with systemic UC-MSC administration were included. Meta-analyses were conducted and expressed as odds ratios (OR) and ratios of the weighted means with 95% CI for categorical and continuous data, respectively. Risk of bias was assessed with the SYRCLE tool.

resultsTwenty-six studies (34 experiments, n = 1258 animals) were included in this review. Overall mortality was significantly reduced with UC-MSC treatment as compared to controls (OR: 0.26, 95% CI: 0.18-0.36). At various prespecified time intervals, UC-MSCs reduced surrogate measures of organ dysfunction related to the kidney, liver, and lung; reduced coagulopathy and endothelial permeability; and enhanced pathogen clearance from multiple sites. UC-MSCs also modulated systemic inflammatory mediators. No studies were rated as low risk across all SYCLE domains.

conclusionsThese results demonstrate the efficacy of UC-MSC treatment in preclinical sepsis models and highlight their potential as a therapeutic intervention for septic shock.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationSepsisUmbilical CordAnimalsDisease Models, AnimalHumansmesenchymal stromal (stem) cellpreclinicalsepsissystematic reviewumbilical cord

Identifiers

PMID38381583
PMCPMC11016835
OpenAlexW4391993956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.