Evidence map›Paper›PMID 38381482›Full record

ArticleeLife2024

Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.

Thomas A Sasani, Aaron R Quinlan, Kelley Harris

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 11 citations in OpenAlex.

  1. Dynamics of mutators of arbitrary dominance in humans.bioRxiv : the preprint server for biology · 2026
    Article
  2. A sibling study of variation in parental mutation rates.bioRxiv : the preprint server for biology · 2026
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  16. The Evolutionary Interplay of Somatic and Germline Mutation Rates.Annual review of biomedical data science · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thomas A SasaniDepartment of Human Genetics, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0003-2317-1374
Aaron R QuinlanDepartment of Human Genetics, University of Utah, Salt Lake City, United States.
Kelley HarrisDepartment of Genome Sciences, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-0302-2523
University of Utah · USUniversity of Washington · US

Funding

New algorithms and tools for large-scale genomic analysesR01HG012252 · NHGRI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Aaron R Quinlan · 2022 to 2026
$3.2M
New algorithms and tools for large-scale genomic analysesR01HG006693 · NHGRI · UNIVERSITY OF VIRGINIA · PI QUINLAN, AARON R · 2012 to 2018
$3.1M
Investigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8M
NHGRI NIH HHS R01 HG006693NHGRI NIH HHS R01 HG012252NHGRI NIH HHS R01HG012252NIGMS NIH HHS R35 GM133428NIGMS NIH HHS R35GM133428
6 · The paper itself

Abstract

Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair,

Indexed as

Epistasis, GeneticGerm-Line MutationAllelesAnimalsChromosome MappingHumansMammalsMiceMutationepistasisevolutionary biologygeneticsgenomicsmousemutational signaturemutation ratemutation spectrumMUTYHQTL mapping

Identifiers

PMID38381482
PMCPMC10942616
OpenAlexW4384835738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.