Evidence map›Paper›PMID 38381462›Full record

ArticleJournal of feline medicine and surgery2024

Effect of tamsulosin on urethral tone in healthy male cats.

Zhe Wang, Amanda Diaz, Rachael Isdale, Kristine Kofron, Susan V Carr, Michael Lappin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhe WangDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-7084-7678
Amanda DiazDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Rachael IsdaleDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Kristine KofronDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Susan V CarrDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Michael LappinDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAlpha-adrenergic antagonists are commonly used to prevent recurrent urethral obstruction in cats with mixed reports of efficacy. No published data on tamsulosin use in cats are available. The objective of this study was to measure changes in urodynamic parameters and blood pressure in five healthy male cats before and after administration of tamsulosin orally for 4 and 10 days.

methodsFive young healthy adult male cats from a research colony were administered tamsulosin at 0.1 mg/cat PO q24h for 10 days. Urethral pressure profile and blood pressure measurements were performed before treatment and approximately 6 h after treatment on days 4 and 10. Maximum urethral closure pressure (MUCP) for the prostatic and penile urethra, functional urethral length (FPL), functional area (FA) and systolic blood pressures were recorded and compared between the time points.

resultsSignificant changes in blood pressure on day 4 (121.1 mmHg ± 20.2 mmHg) and on day 10 (112.6 mmHg ± 14.9 mmHg) compared with day 0 (141.1 mmHg± 33.4 mmHg) were not detected ( CONCLUSIONS AND RELEVANCE: Tamsulosin at 0.1 mg/cat PO q24h did not induce hypotension in healthy cats. Urodynamic testing performed 6 h after the tamsulosin pill was administered did not detect consistent decreases in urodynamic functions induced by tamsulosin. Repeated catheterization of tom cats with 3.5 Fr catheters may induce significant urethral trauma.

Indexed as

Cat DiseasesUrethral ObstructionAnimalsBlood PressureCatsHealth StatusMaleTamsulosinUrethraTamsulosincatheterizationTamsulosinurethral pressure profileurethral tone

Identifiers

PMID38381462
PMCPMC10911306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.