ArticleJapanese journal of radiology2024
The value of preoperative diagnosis of colorectal adenocarcinoma pathological T staging based on dual-layer spectral-detector computed tomography extracellular volume fraction: a preliminary study.
Article in Japanese journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Quantitative dual-energy computed tomography parameters as imaging biomarkers for assessing the histopathologic grade of colorectal cancer.Quantitative imaging in medicine and surgery · 2026Article
- Dual-layer spectral detector computed tomography of peritumoral fat for preoperative prediction of tumor budding in colorectal adenocarcinoma.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferation status in rectal cancer: comparison with diffusion kurtosis imaging.Insights into imaging · 2026Article
- Article
- Parameters of dual-layer spectral detector CT for differentiating pathological types of colorectal adenocarcinoma.Insights into imaging · 2026Article
- Predicting muscle-invasive bladder cancer with dual-layer detector spectral CT-derived extracellular volume fraction.BMC medical imaging · 2026Article
- Research progress of the clinical application of dual-layer spectral computed tomography in gastrointestinal malignancies.World journal of radiology · 2026Review
- Spectral CT imaging in colorectal cancer: current applications, limitations, and future perspectives.Insights into imaging · 2026Review
- Predictive value of multivariate models combining CT-based extracellular volume fraction with clinicopathological parameters for preoperative detection of occult lymph node metastasis in gastric cancer.Insights into imaging · 2025Article
- Diagnostic accuracy of dual-layer spectral computed tomography virtual monoenergetic imaging with multiplanar reformation for T-staging of colorectal cancer.World journal of gastroenterology · 2025Article
- The clinical applications of dual-layer spectral detector CT in digestive system diseases.European radiology · 2025Review
- Photon-counting CT in cancer radiotherapy: technological advances and clinical benefits.Physics in medicine and biology · 2025Review
- Predictive value of dual-energy CT assessment of extracellular volume fraction on efficacy of immune checkpoint inhibitors in patients with liver cancer.Frontiers in oncology · 2025Article
- Early rectal neoplasm in dual-layer spectral detector computed tomography: dual-layer spectral computed tomography (CT) images improve tumor detection and staging.Quantitative imaging in medicine and surgery · 2024Article
- Nomogram based on dual-energy CT-derived extracellular volume fraction for the prediction of microsatellite instability status in gastric cancer.Frontiers in oncology · 2024Article
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Abstract
purposeTo investigate the value of preoperative diagnosis of colorectal adenocarcinoma (CRAC) pathological T staging based on dual-layer spectral-detector computed tomography (DLCT) extracellular volume fraction (ECV) of CRAC lesions.
methodsWe prospectively collected clinical and DLCT imaging data from 165 patients with CRAC who attended two hospitals from June 2022 to April 2023. The enrolled patients were divided into a training group (n = 110, from Hospital 1) and an external validation group (n = 55, from Hospital 2). Measuring and calculating DLCT parameters of lesions, including CT values of 40 and 100 keV virtual mono-energetic images (VMI), iodine concentration (IC) and effective atomic number (Eff-Z) in the arterial phases (AP) and venous phases (VP), and ECV in the delayed phase (DP). The differences in clinical characteristics and DLCT parameters were compared between different pT subgroups. The correlation between DLCT parameters and pT stages were evaluated by Spearman correlation analysis. A multifactorial binary logistic stepwise forward regression analysis was performed to obtain independent influences associated with pT stage. Receiver operating characteristic curves (ROCs) were used to assess diagnostic efficacy and were expressed as area under the curve (AUC).
resultsEach DLCT parameter was higher in pT3 stage tumors than in pT1-2 stage tumors (all P < 0.05). The highest correlation was found between ECV and pT stage (r = 0.637). ECV were independent influences associated with pT stage. ECV had excellent diagnostic efficacy for CRAC pT staging in both the training and external validation groups (AUC = 0.919 and 0.892).
conclusionECV based on DLCT measurement can be used for preoperative noninvasive diagnosis of CRAC pT staging with excellent diagnostic efficacy. It can provide a new imaging marker for the preoperative evaluation of CRAC and help clinicians formulate individualized treatment earlier. However, it needs to be confirmed with a larger sample size.
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