Evidence map›Paper›PMID 38381187›Full record

ArticleSchmerz (Berlin, Germany)2025

[Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach : German version].

Matthew C Mauck, Aileen F Aylward, Chloe E Barton, Brandon Birckhead, Timothy Carey, Diane M Dalton, Aaron J Fields, Julie Fritz, Afton L Hassett, Anna Hoffmeyer and 8 more

Abstract readEnglish Abstract
PubMed Publisher
In one paragraph

Article in Schmerz (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Matthew C MauckDepartment of Anesthesiology, University of North Carolina at Chapel Hill, CB#7011, 27599-7010, Chapel Hill, NC, USA. matt_mauck@med.unc.edu.
Aileen F AylwardDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chloe E BartonDepartment of Anesthesiology, University of North Carolina at Chapel Hill, CB#7011, 27599-7010, Chapel Hill, NC, USA.
Brandon BirckheadDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Timothy CareyDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Diane M DaltonDepartment of Physical Therapy, Boston University, College of Health and Rehabilitation Sciences, Sargent, Boston, MA, USA.
Aaron J FieldsDepartment of Orthopaedic Surgery, University of California San Francisco, San Francisco, Kalifornien, USA.
Julie FritzDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Afton L HassettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Anna HoffmeyerUniversity of North Carolina at Chapel Hill, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA.
Sara B JonesDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Samuel A McLeanDepartment of Anesthesiology, University of North Carolina at Chapel Hill, CB#7011, 27599-7010, Chapel Hill, NC, USA.
Wolf E MehlingDepartment of Family and Community Medicine, University of California San Francisco, San Francisco, Kalifornien, USA.
Conor W O'NeillSection of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, Kalifornien, USA.
Michael J SchneiderDepartment of Physical Therapy and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
David A WilliamsDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Patricia ZhengSection of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, Kalifornien, USA.
Ajay D WasanDepartments of Anesthesiology and Perioperative Medicine and Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic low back pain (cLBP) is highly prevalent in the United States and globally, resulting in functional impairment and lowered quality of life. While many treatments are available for cLBP, clinicians have little information about which specific treatment(s) will work best for individual patients or subgroups of patients. The Back Pain Research Consortium, part of the National Institutes of Health Helping to End Addiction Long-term

objectiveThe primary objective of this article is to provide an update on evidence-based cLBP interventions and describe the process of reviewing and selecting interventions for inclusion in the clinical trial.

methodsA working group of cLBP experts reviewed and selected interventions for inclusion in the clinical trial. The primary evaluation measures were strength of evidence and magnitude of treatment effect. When available in the literature, duration of effect, onset time, carryover effect, multimodal efficacy, responder subgroups, and evidence for the mechanism of treatment effect or biomarkers were considered.

conclusionThe working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.

Indexed as

Chronic PainEvidence-Based MedicineLow Back PainPrecision MedicineCombined Modality TherapyGermanyHumansChronic low back painInterventionsPragmatic clinical trial

Identifiers

PMID38381187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.