Evidence map›Paper›PMID 38381130›Full record

ArticleeLife2024

Mobile barrier mechanisms for Na

Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback and 4 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Structure and allostery in major facilitator superfamily symport mechanisms.Acta crystallographica. Section D, Structural biology · 2026
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  4. Allosteric effects of the coupling cation in melibiose transporter MelB.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Parameswaran HariharanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, United States.ORCID https://orcid.org/0000-0002-6020-1547
Yuqi ShiThermo Fisher Scientific, San Jose, United States.ORCID https://orcid.org/0009-0000-0825-7933
Satoshi KatsubeDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, United States.
Katleen WillibalVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, Brussels, Belgium.
Nathan D BurrowsDivision of CryoEM and Bioimaging, Stanford Synchrotron Radiation Light Source, SLAC National Accelerator Laboratory, Menlo Park, United States.ORCID https://orcid.org/0000-0002-3973-1017
Patrick MitchellDivision of CryoEM and Bioimaging, Stanford Synchrotron Radiation Light Source, SLAC National Accelerator Laboratory, Menlo Park, United States.ORCID https://orcid.org/0000-0002-3458-6930
Amirhossein BakhtiiariDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States.
Samantha StanfieldDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, United States.
Els PardonVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, Brussels, Belgium.ORCID https://orcid.org/0000-0002-2466-0172
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0003-0683-5810
Ruibin LiangDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States.ORCID https://orcid.org/0000-0001-8741-1520
Jan SteyaertVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, Brussels, Belgium.ORCID https://orcid.org/0000-0002-3825-874X
Rosa VinerThermo Fisher Scientific, San Jose, United States.
Lan GuanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, United States.ORCID https://orcid.org/0000-0002-2274-361X

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Integrated approaches to symport mechanisms of membrane transportersR01GM122759 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM122759NIGMS NIH HHS U24 GM129541
6 · The paper itself

Abstract

While many 3D structures of cation-coupled transporters have been determined, the mechanistic details governing the obligatory coupling and functional regulations still remain elusive. The bacterial melibiose transporter (MelB) is a prototype of major facilitator superfamily transporters. With a conformation-selective nanobody, we determined a low-sugar affinity inward-facing Na

Indexed as

Membrane Transport ProteinsSodium ChlorideCationsIon TransportSugarsCationsMembrane Transport ProteinsSodium ChlorideSugarscryoEME. coliH/D exchange-msITC bindingmembrane protein structuremolecular biophysicsnanobodystructural biologysubstrate translocationsymportertransport mechanisms

Identifiers

PMID38381130
PMCPMC10942615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.