Evidence map›Paper›PMID 38381083›Full record

ReviewMicrobial biotechnology2024

On the ever-growing functional versatility of the CRISPR-Cas13 system.

Roser Montagud-Martínez, Rosa Márquez-Costa, María Heras-Hernández, Roswitha Dolcemascolo, Guillermo Rodrigo

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roser Montagud-MartínezInstitute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.
Rosa Márquez-CostaInstitute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.
María Heras-HernándezInstitute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.
Roswitha DolcemascoloInstitute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.
Guillermo RodrigoInstitute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.ORCID 0000-0002-1871-9617

Funding

Consejo Superior de Investigaciones Cientificas JAEINT-19-00844European Commission 813239Generalitat Valenciana GVA-COVID19/2021/036Generalitat Valenciana SEJI-2020-011Ministerio de Ciencia e Innovación PDC2022-133941-I00Ministerio de Ciencia e Innovación PGC2018-101410-B-I00Ministerio de Ciencia e Innovación PRE2019-088531
6 · The paper itself

Abstract

CRISPR-Cas systems evolved in prokaryotes to implement a powerful antiviral immune response as a result of sequence-specific targeting by ribonucleoproteins. One of such systems consists of an RNA-guided RNA endonuclease, known as CRISPR-Cas13. In very recent years, this system is being repurposed in different ways in order to decipher and engineer gene expression programmes. Here, we discuss the functional versatility of the CRISPR-Cas13 system, which includes the ability for RNA silencing, RNA editing, RNA tracking, nucleic acid detection and translation regulation. This functional palette makes the CRISPR-Cas13 system a relevant tool in the broad field of systems and synthetic biology.

Indexed as

CRISPR-Cas SystemsProkaryotic CellsRibonucleoproteinsRNASynthetic BiologyRibonucleoproteinsRNA

Identifiers

PMID38381083
PMCPMC10880580

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.