Evidence map›Paper›PMID 38380961›Full record

ArticlemBio2024

Genetic manipulation of an

Nisha Singh, Agustin Rolandelli, Anya J O'Neal, L Rainer Butler, Sourabh Samaddar, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. PathogenicJournal of bacteriology · 2024
    Review
  4. Article
  5. Rab27 in tick extracellular vesicle biogenesis and infection.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nisha SinghDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Agustin RolandelliDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Anya J O'NealDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
L Rainer ButlerDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Sourabh SamaddarDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0003-0746-3924
Hanna J Laukaitis-YouseyDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0002-2267-4634
Matthew ButnaruDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Stephanie E MohrDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Joao H F PedraDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0001-8740-2667
University of Maryland, Baltimore · USHoward Hughes Medical Institute · USHarvard University · US

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI UTPAL PAL · 2018 to 2026
$13.5M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
Establishing CRISPR cell screening for the deer tick Ixodes scapularis, a vector of Lyme and other diseasesR21AI168592 · NIAID · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E, PEDRA, JOAO · 2022 to 2023
$469k
Regulation of Skin Immunity by a Tick BiteR21AI165520 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2022 to 2023
$425k
Characterization of a Lipid Receptor in Tick Humoral ImmunityF31AI152215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI O’NEAL, ANYA JOSEPHINE · 2020 to 2021
$81k
Rab27 in tick extracellular vesicle biogenesisF31AI167471 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BUTLER, LILLIAN RAINER · 2022 to 2023
$77k
NIAID NIH HHS F31 AI152215NIAID NIH HHS F31 AI167471NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696NIAID NIH HHS R21 AI165520NIAID NIH HHS R21 AI168592NIAID NIH HHS T32 AI162579
6 · The paper itself

Abstract

Although genetic manipulation is one of the hallmarks of model organisms, its applicability to non-model species has remained difficult due to our limited understanding of their fundamental biology. For instance, manipulation of a cell line originated from the black-legged tick

Indexed as

Anaplasma phagocytophilumBorrelia burgdorferiIxodesRickettsiaAnimalsCell LineHumansMammalsBorrelia burgdorferiLyme diseaserickettsiatick-borne diseasesticks

Identifiers

PMID38380961
PMCPMC10936194
OpenAlexW4391995664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.