Evidence map›Paper›PMID 38380883›Full record

ArticleACS applied bio materials2024

Chitosan Poly(vinyl alcohol) Methacrylate Hydrogels for Tissue Engineering Scaffolds.

Nghia Le Ba Thai, Henry T Beaman, Megan Perlman, Ernest E Obeng, Changling Du, Mary Beth B Monroe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nghia Le Ba ThaiDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
Henry T BeamanDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
Megan PerlmanDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
Ernest E ObengDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
Changling DuDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.ORCID 0009-0008-4745-206X
Mary Beth B MonroeDepartment of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.ORCID 0000-0003-4540-5303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major challenge in tissue engineering scaffolds is controlling scaffold degradation rates during healing while maintaining mechanical properties to support tissue formation. Hydrogels are three-dimensional matrices that are widely applied as tissue scaffolds based on their unique properties that can mimic the extracellular matrix. In this study, we develop a hybrid natural/synthetic hydrogel platform to tune the properties for tissue engineering scaffold applications. We modified chitosan and poly(vinyl alcohol) (PVA) with photo-cross-linkable methacrylate functional groups and then synthesized a library of chitosan PVA methacrylate hydrogels (ChiPVAMA) with two different photoinitiators, Irgacure 2959 (I2959) and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). ChiPVAMA hydrogels showed tunability in degradation rates and mechanical properties based on both the polymer content and photoinitiator type. This tunability could enable their application in a range of tissue scaffold applications. In a 2D scratch wound healing assay, all hydrogel samples induced faster wound closure compared to a gauze clinical wound dressing control. NIH/3T3 cells encapsulated in hydrogels showed a high viability (∼92%) over 14 days, demonstrating the capacity of this system as a supportive cell scaffold. In addition, hydrogels containing a higher chitosan content demonstrated a high antibacterial capacity. Overall, ChiPVAMA hydrogels provide a potential tissue engineering scaffold that is tunable, degradable, and suitable for cell growth.

Indexed as

Biocompatible MaterialsChitosanHydrogelsMethacrylatesPolyvinyl AlcoholTissue ScaffoldsAnimalsAnti-Bacterial AgentsCell SurvivalMaterials TestingMiceMicrobial Sensitivity TestsMolecular StructureNIH 3T3 CellsParticle SizeTissue EngineeringAnti-Bacterial AgentsBiocompatible MaterialsChitosanHydrogelsMethacrylatesPolyvinyl AlcoholAntimicrobialChitosanCytocompatbilityHydrogelsPoly(vinyl alcohol)Tissue Engineering

Identifiers

PMID38380883
PMCPMC11653253

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.