Evidence map›Paper›PMID 38380810›Full record

ArticleThe Clinical neuropsychologist2024

Nocturnal hypoglycemia is associated with next day cognitive performance in adults with type 1 diabetes: Pilot data from the GluCog study.

Miranda Zuniga-Kennedy, Olivia H Wang, Luciana M Fonseca, Michael J Cleveland, Jane D Bulger, Elizabeth Grinspoon, Devon Hansen, Zoë W Hawks, Laneé Jung, Shifali Singh and 6 more

Abstract read
In one paragraph

Article in The Clinical neuropsychologist, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. User evaluation of the Hypo-METRICS app: A tool for real-time symptom reporting of hypoglycaemia.Diabetic medicine : a journal of the British Diabetic Association · 2026
    Article
  4. Article
  5. Article
  6. Nocturnal Hypoglycemia in the Era of Continuous Glucose Monitoring.Journal of diabetes science and technology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Miranda Zuniga-KennedyDepartment of Psychology, Washington State University, Pullman, WA, USA.
Olivia H WangElson S, Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Luciana M FonsecaElson S, Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Michael J ClevelandDepartment of Psychology, Washington State University, Pullman, WA, USA.
Jane D BulgerDepartment of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Elizabeth GrinspoonMcLean Hospital, Belmont, MA, USA.
Devon HansenElson S, Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Zoë W HawksMcLean Hospital, Belmont, MA, USA.
Laneé JungMcLean Hospital, Belmont, MA, USA.
Shifali SinghHarvard Medical School, McLean Hospital, Belmont, MA, USA.
Martin SliwinskiDepartment of Human Development and Family Studies, Pennsylvania State University, University Park, PA, USA.
Alandra VerdejoJaeb Center for Health Research, Tampa, FL, USA.
Kellee M MillerT1D Exchange, Boston, MA, USA.
Ruth S WeinstockDepartment of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Laura GermineMcLean Hospital, Belmont, MA, USA.
Naomi ChaytorElson S, Floyd College of Medicine, Washington State University, Spokane, WA, USA.ORCID 0000-0001-8821-289X

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 DiabetesR01DK121240 · NIDDK · MCLEAN HOSPITAL · PI CHAYTOR, NAOMI SAGE, GERMINE, LAURA THI · 2019 to 2022
$3.1M
NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK121240
6 · The paper itself

Abstract

objectiveIndividuals with type 1 diabetes (T1D) have increased risk for cognitive dysfunction and high rates of sleep disturbance. Despite associations between glycemia and cognitive performance using cross-sectional and experimental methods few studies have evaluated this relationship in a naturalistic setting, or the impact of nocturnal versus daytime hypoglycemia. Ecological Momentary Assessment (EMA) may provide insight into the dynamic associations between cognition, affective, and physiological states. The current study couples EMA data with continuous glucose monitoring (CGM) to examine the within-person impact of nocturnal glycemia on next day cognitive performance in adults with T1D. Due to high rates of sleep disturbance and emotional distress in people with T1D, the potential impacts of sleep characteristics and negative affect were also evaluated.

methodsThis pilot study utilized EMA in 18 adults with T1D to examine the impact of glycemic excursions, measured using CGM, on cognitive performance, measured

resultsResults indicated that increases in nocturnal hypoglycemia were associated with slower next day processing speed. This association was not significantly attenuated by negative affect, sleepiness, or sleep quality.

conclusionsThese results, while preliminary due to small sample size, showcase the power of intensive longitudinal designs using ambulatory cognitive assessment to uncover novel determinants of cognitive fluctuation in real world settings, an approach that may be utilized in other populations. Findings suggest reducing nocturnal hypoglycemia may improve cognition in adults with T1D.

Indexed as

Diabetes Mellitus, Type 1Ecological Momentary AssessmentHypoglycemiaAdultBlood GlucoseBlood Glucose Self-MonitoringCognitionCognitive DysfunctionFemaleHumansMaleMiddle AgedPilot ProjectsBlood Glucosecognitionecological momentary assessmenthyperglycemiahypoglycemianegative affectprocessing speedsleepType 1 diabetes

Identifiers

PMID38380810
PMCPMC11336034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.