Evidence map›Paper›PMID 38380643›Full record

ArticleACS sensors2024

Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection.

Blaise J Ostertag, Ayah J Syeed, Alexandra K Brooke, Kamya D Lapsley, Evan J Porshinsky, Ashley E Ross

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Blaise J OstertagDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.
Ayah J SyeedDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.
Alexandra K BrookeDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.
Kamya D LapsleyDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.
Evan J PorshinskyDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.
Ashley E RossDepartment of Chemistry, University of Cincinnati, 312 College Dr. 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.ORCID 0000-0003-2456-3636
University of Cincinnati · US

Funding

Monitoring neurochemical signaling dynamics in the lymph nodeR01AI151552 · NIAID · UNIVERSITY OF CINCINNATI · PI ROSS, ASHLEY E · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI151552
6 · The paper itself

Abstract

We present an optimized synthetic method for repurposing coffee waste to create controllable, uniform porous carbon frameworks for biosensor applications to enhance neurotransmitter detection with fast-scan cyclic voltammetry. Harnessing porous carbon structures from biowastes is a common practice for low-cost energy storage applications; however, repurposing biowastes for biosensing applications has not been explored. Waste coffee ground-derived porous carbon was synthesized by chemical activation to form multivoid, hierarchical porous carbon, and this synthesis was specifically optimized for porous uniformity and electrochemical detection. These materials, when modified on carbon-fiber microelectrodes, exhibited high surface roughness and pore distribution, which contributed to significant improvements in electrochemical reversibility and oxidative current for dopamine (3.5 ± 0.4-fold) and other neurochemicals. Capacitive current increases were small, showing evidence of small increases in electroactive surface area. Local trapping of dopamine within the pores led to improved electrochemical reversibility and frequency-independent behavior. Overall, we demonstrate an optimized biowaste-derived porous carbon synthesis for neurotransmitter detection for the first time and show material utility for viable neurotransmitter detection within a tissue matrix. This work supports the notion that controlled surface nanogeometries play a key role in electrochemical detection.

Indexed as

CarbonCoffeeDopamineNeurotransmitter AgentsPorosityCarbonCoffeeDopamineNeurotransmitter Agentsbiomasselectrochemistryporous carbonrecycled wastesensorsvoltammetry

Identifiers

PMID38380643
PMCPMC11209848
OpenAlexW4391996694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.