ArticleAging cell2024
Metabolomic age and risk of 50 chronic diseases in community-dwelling adults: A prospective cohort study.
Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Frailty and risk of common chronic diseases among cancer survivors: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
- Early life sugar rationing and ageing related diseases, biological ageing and mortality.Nature communications · 2026Article
- Metabolomic ageing across mental and behavioural disorders.BMJ mental health · 2026Article
- A multimodal ocular aging index reveals proteomic pathways and predicts incident age-related eye diseases.npj aging · 2026Article
- Amino acid-based biological age clock and its implications for human health and aging.Nature communications · 2026Article
- Vitamin D Deficiency in Institutionalized Older Adults: Associations with Supplementation Practices but Not with Cognitive Decline or Dementia.Nutrients · 2026Article
- Personalized nutrition for healthy aging: precision diets based on genomic, metabolic, and microbiome profiles.Frontiers in nutrition · 2026Review
- Metabolic dysregulation and biological age acceleration in Hashimoto's thyroiditis: a cross-sectional study based on clinical biomarker aging indices and metabolomics.Frontiers in endocrinology · 2026Article
- The mechanisms, epidemiology, and clinical implications of thyroid hormones and age-related macular degeneration: a narrative review.Frontiers in medicine · 2026Review
- Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks.Communications medicine · 2025Article
- Profile of biological aging in first primary cancers: a pan-cancer analysis of two large-scale cohorts from the UK and Hong Kong.BMC medicine · 2025Article
- Metabolomic-based aging clocks.npj metabolic health and disease · 2025Review
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- A Scoping Review of Epigenetic Signatures of Diet and Diet-related Metabolites: Insights from Epigenome-Wide Association Studies and Their Implications for Cardiometabolic Health and Diseases.The Yale journal of biology and medicine · 2025Article
- Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity-related morbidities.Aging cell · 2025Article
- [Biological Aging Affects the Rate of Cognitive Decline in Middle-aged and Elderly Populations: A Cohort Study Based on CHARLS].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Plasma Proteomics Reveals Biomarkers and Undulating Changes in Metabolic Aging.Research (Washington, D.C.) · 2025Article
- Article
- Metabolomic age and risk of 50 chronic diseases in community-dwelling adults: A prospective cohort study.Aging cell · 2024Article
- Causal effect of gastroesophageal reflux disease on cataracts: A mendelian randomization study.Advances in ophthalmology practice and researchArticle
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Authors and funding
14 authors.
Funding
Abstract
It is unclear how metabolomic age is associated with the risk of a wide range of chronic diseases. Our analysis included 110,692 participants (training: n = 27,673; testing: n = 27,673; validating: n = 55,346) aged 39-71 years at baseline (2006-2010) from the UK Biobank. Incident chronic diseases were identified using inpatient records, or death registers until January 2021. Predicted metabolomic age was trained and tested based on 168 metabolomics. Metabolomic age was linked to the risk of 50 diseases in the validation dataset. The median follow-up duration for individual diseases ranged from 11.2 years to 11.9 years. After controlling for false discovery rate, chronological age-adjusted age gap (CAAG) was significantly associated with the incidence of 25 out of 50 chronic diseases. After adjustment for full covariates, associations with 15 chronic diseases remained significant. Greater CAAG was associated with increased risk of eight cardiometabolic disorders (including cardiovascular diseases and diabetes), some cancers, alcohol use disorder, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease and age-related macular degeneration. The association between CAAG and risk of peripheral vascular disease, other cardiac diseases, fracture, cataract and thyroid disorder was stronger among individuals with unhealthy diet than in those with healthy diet. The association between CAAG and risk of some conditions was stronger in younger individuals, those with metabolic disorders or low education. Metabolomic age plays an important role in the development of multiple chronic diseases. Healthy diet and high education may mitigate the risk for some chronic diseases due to metabolomic age acceleration.
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