Evidence map›Paper›PMID 38380493›Full record

ArticleThe Journal of laryngology and otology2024

The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment.

Aleksandar Perić, Dejan Gaćeša, Sandra Vezmar Kovačević, Aneta V Perić, Danilo Vojvodić, Stella Georgiou, Evdokia Protopapadakis, Konstantinos Alevizopoulos

Abstract read
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In one paragraph

Article in The Journal of laryngology and otology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Efficacy of hypertonic nasal spray with algae in rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aleksandar PerićDepartment of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-8453-7272
Dejan GaćešaENT Hospital "Dr Žutić", Belgrade, Serbia.
Sandra Vezmar KovačevićDepartment of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University in Belgrade, Belgrade, Serbia.
Aneta V PerićInstitute for Pharmacy, Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Danilo VojvodićInstitute for Medical Research, Division of Clinical and Experimental Immunology, University of Defense, Belgrade, Serbia.
Stella GeorgiouResearch and Development Department, Gerolymatos International S.A., Athens, Greece.
Evdokia ProtopapadakisResearch and Development Department, Gerolymatos International S.A., Athens, Greece.
Konstantinos AlevizopoulosResearch and Development Department, Gerolymatos International S.A., Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate epidermal growth factor, transforming growth factor-α and interleukin-8 production in nasal mucosa irrigated with hypertonic 2.3 per cent solution with algae extracts, in comparison to 0.9 per cent NaCl during the first two weeks after surgery for nasal polyposis, in relation to symptoms and local findings.

methodsThis prospective study included 20 nasal polyposis patients postoperatively irrigated with hypertonic solution and 20 nasal polyposis patients postoperatively irrigated with isotonic solution. We evaluated nasal symptom score, endoscopic score and mediator levels in nasal secretions before and after irrigation.

resultsFollowing treatment, nasal symptom score and endoscopic score were significantly lower in the hypertonic solution group (

conclusionIrrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.

Indexed as

Epidermal Growth FactorInterleukin-8Nasal LavageNasal MucosaNasal PolypsSeawaterTransforming Growth Factor alphaAdultAgedEndoscopyFemaleHumansHypertonic SolutionsMaleMiddle AgedProspective StudiesEpidermal Growth FactorHypertonic SolutionsInterleukin-8Transforming Growth Factor alphaCytokinesnasal lavage fluidnasal mucosanasal polypsnasal surgical proceduressaline solution

Identifiers

PMID38380493
PMCPMC11063653

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.