Evidence map›Paper›PMID 38380477›Full record

ArticleAging cell2024

Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress.

Charles E Norton, Rebecca L Shaw, Safa, Beyoncé Dockery, Timothy L Domeier, Steven S Segal

Abstract read
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0001-9442-4039
Rebecca L ShawDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
SafaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Beyoncé DockeryDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Timothy L DomeierDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Steven S SegalDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.

Funding

Cardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5M
Alzheimer's Association AARG-NTF-1148948American Heart Association 19TPA34850102American Heart Association CDA931652NHLBI NIH HHS R01 HL136292NIH HHS R01HL136292
6 · The paper itself

Abstract

Aging increases reactive oxygen species (ROS) which can impair vascular function and contribute to brain injury. However, aging can also promote resilience to acute oxidative stress. Therefore, we tested the hypothesis that advanced age protects smooth muscle cells (SMCs) and endothelial cells (ECs) of posterior cerebral arteries (PCAs; diameter, ∼80 μm) during exposure to H

Indexed as

AgingApoptosisCerebral ArteriesMice, Inbred C57BLOxidative StressAnimalsCalciumFemaleHydrogen PeroxideMaleMembrane Potential, MitochondrialMiceMitochondriaMyocytes, Smooth MuscleReactive Oxygen SpeciesCalciumHydrogen PeroxideReactive Oxygen Speciesagingapoptosiscalciumcell deathmitochondriaoxidative stressreactive oxygen species

Identifiers

PMID38380477
PMCPMC11113258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.