Evidence map›Paper›PMID 38380428›Full record

ArticleFrontiers in molecular biosciences2024

Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in

Claudia Michaelis, Tamara M I Berger, Kirill Kuhlmann, Rangina Ghulam, Lukas Petrowitsch, Maria Besora Vecino, Bernd Gesslbauer, Tea Pavkov-Keller, Walter Keller, Elisabeth Grohmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Interactive 3D Objects Enhance Scientific Communication of Structural Data.Chembiochem : a European journal of chemical biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Claudia Michaelis *Faculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
Tamara M I Berger *Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Kirill KuhlmannInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Rangina GhulamFaculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
Lukas PetrowitschInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Maria Besora VecinoInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Bernd GesslbauerInstitute of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Graz, Graz, Austria.
Tea Pavkov-KellerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Walter KellerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Elisabeth GrohmannFaculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
University of Graz · ATBerliner Hochschule für Technik · DEBioTechMed-Graz · AT

Funding

Austrian Science Fund FWF DOC 130
6 · The paper itself

Abstract

Conjugation is a major mechanism that facilitates the exchange of antibiotic resistance genes among bacteria. The broad-host-range Inc18 plasmid pIP501 harbors 15 genes that encode for a type IV secretion system (T4SS). It is a membrane-spanning multiprotein complex formed between conjugating donor and recipient cells. The penultimate gene of the pIP501 operon encodes for the cytosolic monomeric protein TraN. This acts as a transcriptional regulator by binding upstream of the operon promotor, partially overlapping with the origin of transfer. Additionally, TraN regulates

Indexed as

antibiotic resistanceconjugative transferDNA binding proteinsEnterococcus faecalispIP501transfer regulatortype IV secretion system

Identifiers

PMID38380428
PMCPMC10877727
OpenAlexW4391576629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.