Evidence map›Paper›PMID 38380348›Full record

ArticleTransplantation direct2024

Extracorporeal Photopheresis Reduces Fibrotic and Inflammatory Transcriptomic Biological Marker of Chronic Antibody-mediated Kidney Rejection.

Arnaud Lionet, Marine Van Triempon, Martin Figeac, Victor Fages, Jean-Baptiste Gibier, François Provot, Mehdi Maanaoui, Nicolas Pottier, Christelle Cauffiez, François Glowacki

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Arnaud LionetDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.ORCID https://orcid.org/0000-0002-1331-3095
Marine Van TriemponDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Martin FigeacCNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41-UAR 2014-PLBS, University of Lille, Lille, France.
Victor FagesDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Jean-Baptiste GibierPathology Departement, CHU-Lille, France.
François ProvotDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Mehdi MaanaouiDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Nicolas PottierCNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277-CANTHER, University of Lille, Lille, France.
Christelle CauffiezCNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277-CANTHER, University of Lille, Lille, France.
François GlowackiDepartment of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Centre National de la Recherche Scientifique · FRHôpital Claude Huriez · FRCentre Hospitalier Universitaire de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The benefit of extracorporeal photopheresis on the course of kidney transplant rejection is unknown. The aim of our study was to investigate the variations in transcriptomics on graft biopsies when extracorporeal photopheresis was used to treat chronic humoral rejection after kidney transplantation. Methods: We retrospectively analyzed the mRNA expression of 770 genes of interest in graft biopsies performed before and after treatment. Eight patients received an average of 23 extracorporeal photopheresis sessions over 4 mo between the 2 biopsies. Results: Transcriptomic analysis of the graft biopsies identified a significant (adjusted Conclusions: In patients treated with extracorporeal photopheresis for chronic humoral rejection after renal transplantation, omic analysis of repeated biopsies shows a reduction in fibrotic and inflammatory transcriptomic biologicals markers.

Identifiers

PMID38380348
PMCPMC10876237
OpenAlexW4391932828

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.