Evidence map›Paper›PMID 38380337›Full record

ArticleMaterials advances2024

3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model.

Zhongchao Zhao, Yi Xiang, Edward C Koellhoffer, Sourabh Shukla, Steven Fiering, Shaochen Chen, Nicole F Steinmetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhongchao ZhaoDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.ORCID https://orcid.org/0000-0002-3736-6677
Yi XiangDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
Edward C KoellhofferDepartment of Radiology, University of California San Diego, 9500 Gilman Dr. La Jolla CA 92093 USA.
Sourabh ShuklaDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
Steven FieringDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA.
Shaochen ChenDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
Nicole F SteinmetzDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.ORCID https://orcid.org/0000-0002-0130-0481

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
Bioprinting Plant Virus Nanoparticles for Immunotherapy and Relapse Prevention of Ovarian CancerR01CA253615 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, FIERING, STEVEN · 2020 to 2024
$3.1M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA253615NIBIB NIH HHS T32 EB005970
6 · The paper itself

Abstract

Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to serve as depots for cancer slow-release immunotherapy. Sustained release of CPMV within the intraperitoneal space alleviates the need for repeated dosing and we demonstrated efficacy against ovarian cancer in a metastatic mouse model.

Identifiers

PMID38380337
PMCPMC10876074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.