Evidence map›Paper›PMID 38380039›Full record

ArticleHeliyon2024

Therapeutic effects of the Qingre-Qushi recipe on atopic dermatitis through the regulation of gut microbiota and skin inflammation.

Fang Shen, Chunjie Gao, Mingxia Wang, Xiaojie Ding, Hang Zhao, Mi Zhou, Jingyi Mao, Le Kuai, Bin Li, Dongming Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Bibliometric Analysis of Traditional Chinese Medicine in Treating Eczema.Clinical, cosmetic and investigational dermatology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Fang ShenShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Chunjie GaoShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Mingxia WangShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Xiaojie DingInstitute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, China.
Hang ZhaoInstitute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, China.
Mi ZhouInstitute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, China.
Jingyi MaoDepartment of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Le KuaiInstitute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, China.
Bin LiShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Dongming WangDepartment of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Huimin ZhangDepartment of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xin MaShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Shanghai University of Traditional Chinese Medicine · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence has highlighted a strong association between gut microbiota and the occurrence, development, prevention, and treatment of atopic dermatitis (AD). The regulation of gut microbial dysbiosis by oral traditional Chinese medicine (TCM) has garnered significant attention. In the treatment of AD, the TCM formula Qingre-Qushi Recipe (QRQS) has demonstrated clinical efficacy. However, both the therapeutic mechanisms of QRQS and its impact on gut microbiota remain unclear. Thus, our study aimed to assess the efficacy of QRQS and evaluate its influence on the composition and diversity of gut microbiota in AD animal models. First, we investigated the therapeutic effect of QRQS on AD using two animal models: filaggrin-deficient mice (Flaky tail, ft/ft) and MC903-induced AD-like mice. Subsequently, we explored its influence on the composition and diversity of gut microbiota. Our results demonstrated that QRQS treatment ameliorated the symptoms in both ft/ft mice and MC903-induced AD-like mice. It also reduced the levels of serum IgE and pro-inflammatory cytokines, including IL-1β, IL-4, IL-5, IL-9, IL-13, IL-17A, and TNF-α. Furthermore, QRQS remarkably regulated gut microbiota diversity by increasing

Indexed as

Atopic dermatitisGut microbiotaQRQSSkin inflammationTraditional Chinese Medicine

Identifiers

PMID38380039
PMCPMC10877368
OpenAlexW4391651396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.