ArticleThe British journal of radiology2024
Fully automated CT imaging biomarkers for opportunistic prediction of future hip fractures.
Article in The British journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- IgeaNet: a deep learning model for opportunistic osteoporosis screening from chest X-ray images.La Radiologia medica · 2026Article
- Multi-center validation of automated CT-based L1 vertebral Hounsfield unit.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Improved prediction of hip fracture using multi-faceted biomechanical computed tomography.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Ratio of visceral-to-subcutaneous fat area improves long-term mortality prediction over either measure alone: automated CT-based AI measures with longitudinal follow-up in a large adult cohort.Abdominal radiology (New York) · 2026Article
- Artificial Intelligence in Rheumatology: From Algorithms to Clinical Impact in Osteoporosis and Chronic Inflammatory Rheumatic Diseases.Journal of clinical medicine · 2026Article
- Artificial intelligence in osteoporosis assessment using CT imaging: a scoping review.Frontiers in medicine · 2026Review
- Methodology for a fully automated pipeline of AI-based body composition tools for abdominal CT.Abdominal radiology (New York) · 2025Article
- Automated abdominal CT imaging biomarkers and clinical frailty measures associated with postoperative deceased-donor liver transplant outcomes.European radiology · 2025Article
- Opportunistic prognostication by computerized tomography (CT) in the emergency department: analysis on 1920 patients and creation of a simple and fast scoring system.La Radiologia medica · 2025Article
- Biological age model using explainable automated CT-based cardiometabolic biomarkers for phenotypic prediction of longevity.Nature communications · 2025Article
- Transferable CNN-based data mining approaches for medical imaging: application to spine DXA scans for osteoporosis detection.Frontiers in computational neuroscience · 2025Article
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7 authors.
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Abstract
objectiveAssess automated CT imaging biomarkers in patients who went on to hip fracture, compared with controls.
methodsIn this retrospective case-control study, 6926 total patients underwent initial abdominal CT over a 20-year interval at one institution. A total of 1308 patients (mean age at initial CT, 70.5 ± 12.0 years; 64.4% female) went on to hip fracture (mean time to fracture, 5.2 years); 5618 were controls (mean age 70.3 ± 12.0 years; 61.2% female; mean follow-up interval 7.6 years). Validated fully automated quantitative CT algorithms for trabecular bone attenuation (at L1), skeletal muscle attenuation (at L3), and subcutaneous adipose tissue area (SAT) (at L3) were applied to all scans. Hazard ratios (HRs) comparing highest to lowest risk quartiles and receiver operating characteristic (ROC) curve analysis including area under the curve (AUC) were derived.
resultsHip fracture HRs (95% CI) were 3.18 (2.69-3.76) for low trabecular bone HU, 1.50 (1.28-1.75) for low muscle HU, and 2.18 (1.86-2.56) for low SAT. 10-year ROC AUC values for predicting hip fracture were 0.702, 0.603, and 0.603 for these CT-based biomarkers, respectively. Multivariate combinations of these biomarkers further improved predictive value; the 10-year ROC AUC combining bone/muscle/SAT was 0.733, while combining muscle/SAT was 0.686.
conclusionOpportunistic use of automated CT bone, muscle, and fat measures can identify patients at higher risk for future hip fracture, regardless of the indication for CT imaging. ADVANCES IN KNOWLEDGE: CT data can be leveraged opportunistically for further patient evaluation, with early intervention as needed. These novel AI tools analyse CT data to determine a patient's future hip fracture risk.
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