Evidence map›Paper›PMID 38379324›Full record

ArticleCancer medicine2024

Assessment of salivary cadmium levels and breast density in the Marin Women's Study.

Michaela F George, Shayne Paff, Jenyse Rojo, Mark Powell, Christopher Benz, Karl Pope, Karla Kerlikowske, John Shepard, Matthew Willis, Rochelle Ereman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michaela F GeorgeGlobal Public Health Department, School of Health and Natural Sciences, Dominican University of California, San Rafael, California, USA.ORCID 0000-0002-0863-6615
Shayne PaffEpidemiology and Community Health, Marin County Department of Health and Human Services, San Rafael, California, USA.ORCID 0000-0002-5406-9375
Jenyse RojoGlobal Public Health Department, School of Health and Natural Sciences, Dominican University of California, San Rafael, California, USA.
Mark PowellZero Breast Cancer, Buck Institute for Research on Aging, San Rafael, California, USA.
Christopher BenzCancer & Developmental Therapeutics, Buck Institute for Research on Aging, San Rafael, California, USA.
Karl PopeEpidemiology and Community Health, Marin County Department of Health and Human Services, San Rafael, California, USA.
Karla KerlikowskeDepartment of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
John ShepardPopulation Sciences in the Pacific Program, Cancer Epidemiology, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Matthew WillisEpidemiology and Community Health, Marin County Department of Health and Human Services, San Rafael, California, USA.
Rochelle EremanGlobal Public Health Department, School of Health and Natural Sciences, Dominican University of California, San Rafael, California, USA.
LeeAnn PrebilEpidemiology and Community Health, Marin County Department of Health and Human Services, San Rafael, California, USA.

Funding

Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Diana L Miglioretti · 2011 to 2026
$52.9M
San Francisco Mammography Registry-A Research SourceU01CA063740 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KERLIKOWSKE, KARLA M · 1994 to 2011
$6.2M
MARIN WOMEN'S STUDY-BREAST CANCER RESEARCHH75DP001730 · DP · COUNTY OF MARIN · PI EREMAN, ROCHELLE R. · 2008 to 2010
$725k
CDC grant no. 5H75 DP001730-2National Cancer Institute-fund no. P01 CA154292, U01 CA63740, HHSN261201100031CNCCDPHP CDC HHS H75 DP001730NCI NIH HHS HHSN261201100031CNCI NIH HHS P01 CA154292NCI NIH HHS U01 CA063740The Avon Foundation grant no. 02-2009-053
6 · The paper itself

Abstract

backgroundWe aimed to determine if salivary cadmium (Cd) levels had any association with breast density, hoping to establish a less invasive cost-effective method of stratifying Cd burden as an environmental breast cancer risk factor.

methodsSalivary Cd levels were quantified from the Marin Women's Study, a Marin County, California population composite. Volumetric compositional breast density (BD

resultsCd was quantifiable in over 90% of saliva samples (mean = 55.7 pg/L, SD = 29). Women with higher saliva Cd levels had a non-significant odds ratio of 1.34 with BI-RAD scores (3 or 4) (95% CI 0.75-2.39, p = 0.329). Cd levels were higher in current smokers (mean = 61.4 pg/L, SD = 34.8) than former smokers or non-smokers. These results were non-significant. Pilot data revealed that higher age and higher BMI were associated with higher BI-RAD scores (p < 0.001).

conclusionSalivary Cd is a viable quantification source in large epidemiologic studies. Association analyses between Cd levels and breast density may provide additional information for breast cancer risk assessment, risk reduction plans, and future research directions. Further work is needed to demonstrate a more robust testing protocol before the extent of its usefulness can be established.

Indexed as

Breast DensityBreast NeoplasmsCadmiumEarly Detection of CancerFemaleHumansMammographyCadmiumbiomarkersbreast cancercancer preventioncancer risk factorscommunity outreachepidemiology

Identifiers

PMID38379324
PMCPMC10831917

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.