Evidence map›Paper›PMID 38379280›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2024

Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy.

Jessica Nevarez-Mejia, Yi-Ping Jin, Harry Pickering, Rajesh Parmar, Nicole M Valenzuela, Rebecca A Sosa, Sebastiaan Heidt, Gregory A Fishbein, Enrique Rozengurt, William M Baldwin and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Gain-of-function mutation inbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Proinflammatory and cytotoxic CD38American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  5. Review
  6. Review
  7. Not all antibodies are created equal: total IgG glycosylation and severity of antibody-mediated rejection in kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jessica Nevarez-MejiaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Yi-Ping JinDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Harry PickeringDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Rajesh ParmarDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Nicole M ValenzuelaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Rebecca A SosaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Sebastiaan HeidtDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Gregory A FishbeinDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
Enrique RozengurtDivision of Digestive Diseases, Department of Medicine, University of California, Los Angeles, California, USA.
William M BaldwinDepartment of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic, Ohio, USA.
Robert L FairchildDepartment of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic, Ohio, USA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA. Electronic address: ereed@mednet.ucla.edu.
University of California, Los Angeles · USCleveland Clinic Lerner College of Medicine · USLeiden University Medical Center · NL

Funding

Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejectionR01AI135201 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2018 to 2026
$5.3M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Targeting YAP with statins to prevent antibody-mediated transplant rejectionR21AI156592 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, ROZENGURT, JUAN ENRIQUE · 2021 to 2022
$444k
NHLBI NIH HHS T32 HL069766NIAID NIH HHS R01 AI135201NIAID NIH HHS R21 AI156592NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

HLA donor-specific antibodies (DSA) elicit alloimmune responses against the graft vasculature, leading to endothelial cell (EC) activation and monocyte infiltration during antibody-mediated rejection (AMR). AMR promotes chronic inflammation and remodeling, leading to thickening of the arterial intima termed transplant vasculopathy or cardiac allograft vasculopathy (CAV) in heart transplants. Intragraft-recipient macrophages serve as a diagnostic marker in AMR; however, their polarization and function remain unclear. In this study, we utilized an in vitro Transwell coculture system to explore the mechanisms of monocyte-to-macrophage polarization induced by HLA I DSA-activated ECs. Anti-HLA I (IgG or F(ab')

Indexed as

Toll-Like Receptor 4Vascular DiseasesAllograftsEndotheliumHLA AntigensHumansImmunoglobulin GMacrophagesMatrix Metalloproteinase 9P-SelectinHLA AntigensImmunoglobulin GMatrix Metalloproteinase 9MMP9 protein, humanP-SelectinTLR4 protein, humanToll-Like Receptor 4antibody-mediated rejection (AMR)areas of interest (AOIs)cardiac allograft vasculopathy (CAV)donor-specific HLA antibodies (DSA)endothelial cell (EC)human leukocyte antigen (HLA)transplant vasculopathy (TV)

Identifiers

PMID38379280
PMCPMC11110958
OpenAlexW4388011816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.