Evidence map›Paper›PMID 38379051›Full record

ArticleNature cell biology2024

Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities.

Tobias Roider, Marc A Baertsch, Donnacha Fitzgerald, Harald Vöhringer, Berit J Brinkmann, Felix Czernilofsky, Mareike Knoll, Laura Llaó-Cid, Anna Mathioudaki, Bianca Faßbender and 15 more

Abstract read
In one paragraph

Article in Nature cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. [Advances in single cell omics applications in mantle cell lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026
    Review
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  16. Mucosa-associated lymphoid tissue lymphoma with monoclonal T-cell expansion.Virchows Archiv : an international journal of pathology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tobias Roider *Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-6973-3531
Marc A Baertsch *Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-4000-6904
Donnacha FitzgeraldDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4927-7484
Harald VöhringerDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-2513-4518
Berit J BrinkmannDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-0457-2159
Felix CzernilofskyDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Mareike KnollEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Laura Llaó-CidDivision of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0003-0543-6084
Anna MathioudakiEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-4617-7015
Bianca FaßbenderDepartment of Hematology and Oncology, University Hospital Düsseldorf, Düsseldorf, Germany.
Maxime HerbonDepartment of Hematology and Oncology, University Hospital Düsseldorf, Düsseldorf, Germany.
Tobias LautweinGenomics and Transcriptomics Laboratory, University of Düsseldorf, Düsseldorf, Germany.
Peter-Martin BruchDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-9992-3109
Nora LiebersEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Christian M SchürchDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1792-1768
Verena PasseriniDepartment of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research, Ludwig-Maximilians-University Hospital, Munich, Germany.
Marc SeifertDepartment of Hematology and Oncology, University Hospital Düsseldorf, Düsseldorf, Germany.
Alexander BrobeilDepartment of Pathology, University of Heidelberg, Heidelberg, Germany.
Gunhild MechtersheimerDepartment of Pathology, University of Heidelberg, Heidelberg, Germany.
Carsten Müller-TidowDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7166-5232
Oliver WeigertGerman Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-0987-7373
Martina SeiffertDivision of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8862-9043
Wolfgang HuberMolecular Medicine Partnership Unit, Heidelberg, Germany. wolfgang.huber@embl.de.ORCID 0000-0002-0474-2218
Sascha DietrichDepartment of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany. sascha.dietrich@embl.de.ORCID 0000-0002-0648-1832

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities is missing. Here we present an in-depth T cell reference map of nodal B-NHL, based on cellular indexing of transcriptomes and epitopes, T cell receptor sequencing, flow cytometry and multiplexed immunofluorescence applied to 101 lymph nodes from patients with diffuse large B cell, mantle cell, follicular or marginal zone lymphoma, and from healthy controls. This multimodal resource revealed quantitative and spatial aberrations of the T cell microenvironment across and within B-NHL entities. Quantitative differences in PD1

Indexed as

Lymphoma, B-Cell, Marginal ZoneT-LymphocytesB-LymphocytesHumansTransforming Growth Factor betaTumor MicroenvironmentTransforming Growth Factor beta

Identifiers

PMID38379051
PMCPMC10940160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.