ArticleNature communications2024
A neural signature for the subjective experience of threat anticipation under uncertainty.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Vasopressin and angiotensin II pathways differentially modulate human fear response dynamics to looming threats.PLoS biology · 2026Trial
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Severe PTSD symptoms magnify episodic memory-encoding deficits and amygdala-ACC attenuation during unpredictable threat in male combat veterans.Molecular psychiatry · 2026Article
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- Hyperarousal transdiagnostically dissected: different dimensions characterize mood, anxiety, insomnia, posttraumatic stress and attention deficit hyperactivity disorders.EClinicalMedicine · 2026Article
- Common and distinct neurofunctional signatures of dynamic naturalistic emotion regulation strategies.Nature communications · 2026Article
- Ecologically-Valid Emotion Signatures Enhance Mood Disorder Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- State and trait serotonin variations interact to shape the intrinsic connectivity and gradient architecture of the brain - a combined TPH2 genetics and tryptophan depletion study in men.Psychopharmacology · 2026Article
- Fear, anxiety, and the extended amygdala-absence of evidence for strict functional segregation.Social cognitive and affective neuroscience · 2026Article
- Fear, anxiety, and the extended amygdala-bioRxiv : the preprint server for biology · 2025Article
- Neurobehavioral mechanisms of fear and anxiety in multiple sclerosis.Communications medicine · 2025Article
- A neurofunctional signature of affective arousal generalizes across valence domains and distinguishes subjective experience from autonomic reactivity.Nature communications · 2025Article
- Enhancing task fMRI individual difference research with neural signatures.medRxiv : the preprint server for health sciences · 2025Article
- The unique role of anosognosia in the clinical progression of Alzheimer's disease: a disorder-network perspective.Communications biology · 2024Review
- Interaction between the prefrontal and visual cortices supports subjective fear.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- A neural signature for the subjective experience of threat anticipation under uncertainty.Nature communications · 2024Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
Uncertainty about potential future threats and the associated anxious anticipation represents a key feature of anxiety. However, the neural systems that underlie the subjective experience of threat anticipation under uncertainty remain unclear. Combining an uncertainty-variation threat anticipation paradigm that allows precise modulation of the level of momentary anxious arousal during functional magnetic resonance imaging (fMRI) with multivariate predictive modeling, we train a brain model that accurately predicts subjective anxious arousal intensity during anticipation and test it across 9 samples (total n = 572, both gender). Using publicly available datasets, we demonstrate that the whole-brain signature specifically predicts anxious anticipation and is not sensitive in predicting pain, general anticipation or unspecific emotional and autonomic arousal. The signature is also functionally and spatially distinguishable from representations of subjective fear or negative affect. We develop a sensitive, generalizable, and specific neuroimaging marker for the subjective experience of uncertain threat anticipation that can facilitate model development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.