ArticleScientific reports2024
Association between triglyceride glucose index and total bone mineral density: a cross-sectional study from NHANES 2011-2018.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A systematic review of the association between insulin resistance surrogate indices and bone mineral density.Frontiers in endocrinology · 2024Pooled it
- TyG-BMI as a Marker of Metabolic Status and Its Association with Bone Quality and Mineral Metabolism: A Sex-Specific Analysis.Journal of clinical medicine · 2026Article
- Association between serum uric acid levels and lumbar spine Z-scores in adults aged <50 years: A cross-sectional study.Metabolism open · 2026Article
- Body roundness index and its association with QUS-defined osteoporosis and bone mineral density in middle-aged and older adults: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- Predictive value of insulin resistance related indicators for osteoporosis risk in patients with type 2 diabetes mellitus: a real-world study.Frontiers in molecular biosciences · 2026Article
- Adiposity indices and bone health amongst Malaysian adults: Evidence from a cross-sectional study.Experimental and therapeutic medicine · 2026Article
- Association between the triglyceride glucose-waist-to-height ratio and stroke risk among middle-aged and elderly Chinese adults.BMC endocrine disorders · 2025Article
- Article
- Triglyceride-glucose index, a silent predictor for osteosarcopenic adiposity occurrence and risk of cardiovascular and all-cause mortality.Diabetology & metabolic syndrome · 2025Article
- Associations of the Neutrophil-to-Lymphocyte Ratio(NLR), Triglyceride-Glucose Index (TyG), and TyG-derived indices with vitality decline in older adults in China: a study within the Integrated Care for Older People (ICOPE) framework.Lipids in health and disease · 2025Article
- Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- A Review of the Relationship Between Insulin and Bone Health.Biomedicines · 2025Review
- Association of triglyceride glucose and obesity indices with chronic obstructive pulmonary disease in US adults: data from 2013 to 2018 NHANES.BMC pulmonary medicine · 2025Article
- Association between triglyceride‑glucose index and lumbar bone mineral density among Chinese individuals with osteoporotic fractures: a cross sectional study.Scientific reports · 2025Article
- Association between the indicators of insulin resistance and periodontitis: a study using data from the National Health and Nutrition Examination Survey 2009-2014.BMC oral health · 2025Article
- Association of triglyceride-glucose index with bone mineral density and fracture: a systematic review.Diabetology & metabolic syndrome · 2025Review
- Insulin resistance and periodontitis: Mediation by blood pressure.Journal of periodontal research · 2025Article
- Association between Heavy metals and triglyceride-glucose-related index: a mediation analysis of inflammation indicators.Lipids in health and disease · 2025Article
- An association between average daily sleep duration and gallstones in US adults.Scientific reports · 2025Article
- Development and evaluation of interpretable machine learning regressors for predicting femoral neck bone mineral density in elderly men using NHANES data.Biomolecules & biomedicine · 2025Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Homeostatic Model Assessment for Triglyceride Glucose Index (TyG) and its related indices, including triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist-to-height ratio (TyG-WHtR) and triglyceride glucose-body mass index (TyG-BMI), has emerged as a practical tool for assessing insulin resistance in metabolic disorders. However, limited studies have explored the connection between TyG, TyG-related indices and osteoporosis. This population-based study, utilizing data from the National Health and Nutrition Examination Survey 2011-2018, involved 5456 participants. Through weighted multivariate linear regression and smoothed curve fitting, a significant positive correlation was found between TyG, TyG-related indices and total bone mineral density (BMD) after adjusting for covariates [β = 0.0124, 95% CI (0.0006, 0.0242), P = 0.0390; β = 0.0004, 95% CI (0.0003, 0.0004), P < 0.0001; β = 0.0116, 95% CI (0.0076, 0.0156), P < 0.0001; β = 0.0001, 95% CI (0.0001, 0.0001), P < 0.0001]. In subgroup analysis, race stratification significantly affected the relationship between TyG and total BMD. Additionally, gender and race were both significant for TyG-related indices. Non-linear relationships and threshold effects with inflection points at 9.106, 193.9265, 4.065, and 667.5304 (TyG, TyG-BMI, TyG-WHtR, TyG-WC) were identified. Saturation phenomena were observed between TyG-BMI, TyG-WC and total BMD with saturation thresholds at 314.177 and 1022.0428. These findings contributed to understanding the association between TyG, TyG-related indices and total BMD, offering insights for osteoporosis prevention and treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.