Evidence map›Paper›PMID 38378826›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use.

Kurlen S E Payton, Mihoko V Bennett, Joseph Schulman, William E Benitz, Lisa Stellwagen, Gary L Darmstadt, Jenny Quinn, Alexandria I Kristensen-Cabrera, Courtney C Breault, Michael Bolaris and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kurlen S E PaytonDepartment of Pediatrics, Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. kurlen.payton@cshs.org.ORCID 0000-0003-2790-5849
Mihoko V BennettCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.ORCID 0000-0002-3449-9538
Joseph SchulmanCA Department of Health Care Services, California Children's Services, Sacramento, CA, USA.ORCID 0000-0002-8560-3972
William E BenitzDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3645-3346
Lisa StellwagenDepartment of Pediatrics, Division of Academic General Pediatrics, University of California San Diego School of Medicine, San Diego, CA, USA.
Gary L DarmstadtPrematurity Research Center, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jenny QuinnCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.ORCID 0000-0001-7538-860X
Alexandria I Kristensen-CabreraCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
Courtney C BreaultCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
Michael BolarisDepartment of Pediatrics, Division of Infectious Disease, Harbor-University of California Los Angeles Medical Center, Los Angeles, CA, USA.
Linda LefrakCalifornia Department of Public Health, Center for Health Care Quality, Health Care Associated Infections Program, Richmond, CA, USA.
Jeff MerrillSutter Health Summit Medical Center, Oakland, CA, USA.
Paul J SharekCalifornia Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management. STUDY

designTwenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs.

resultAggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention.

conclusionParticipation in this multicenter NICU antibiotic stewardship collaborative targeting EOS was associated with an aggregate reduction in antibiotic use. This study informs efforts aimed at sustaining improvements in NICU AURs.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipIntensive Care Units, NeonatalNeonatal SepsisQuality ImprovementCross InfectionFemaleHumansInfant, NewbornSepsisAnti-Bacterial Agents

Identifiers

PMID38378826
PMCPMC11226396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.