Evidence map›Paper›PMID 38378784›Full record

ArticleNature communications2024

Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida.

Huang Li, Soujanya Akella, Carina Engstler, Joy J Omini, Moira Rodriguez, Toshihiro Obata, Chris Carrie, Heriberto Cerutti, Jeffrey P Mower

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Huang LiCenter for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0003-4154-818X
Soujanya AkellaCenter for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0002-6178-0843
Carina EngstlerDepartment Biologie I-Botanik, Ludwig-Maximilians-Universität München, D-82152, Planegg-Martinsried, Germany.
Joy J OminiDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Moira RodriguezSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0001-8780-5466
Toshihiro ObataCenter for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0001-8931-7722
Chris CarrieSchool of Biological Sciences, University of Auckland, Auckland, 1142, New Zealand.ORCID 0000-0002-4240-4674
Heriberto CeruttiCenter for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0002-3158-1368
Jeffrey P MowerCenter for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA. jpmower@unl.edu.ORCID 0000-0002-1501-5809
University of Nebraska–Lincoln · USBernstein Center for Computational Neuroscience Munich · DEUniversity of Auckland · NZ

Funding

National Science Foundation (NSF) MCB 2212075
6 · The paper itself

Abstract

Mitochondrial cytochrome c maturation (CCM) requires heme attachment via distinct pathways termed systems I and III. The mosaic distribution of these systems in Archaeplastida raises questions about the genetic mechanisms and evolutionary forces promoting repeated evolution. Here, we show a recurrent shift from ancestral system I to the eukaryotic-specific holocytochrome c synthase (HCCS) of system III in 11 archaeplastid lineages. Archaeplastid HCCS is sufficient to rescue mutants of yeast system III and Arabidopsis system I. Algal HCCS mutants exhibit impaired growth and respiration, and altered biochemical and metabolic profiles, likely resulting from deficient CCM and reduced cytochrome c-dependent respiratory activity. Our findings demonstrate that archaeplastid HCCS homologs function as system III components in the absence of system I. These results elucidate the evolutionary trajectory and functional divergence of CCM pathways in Archaeplastida, providing insight into the causes, mechanisms, and consequences of repeated cooption of an entire biological pathway.

Indexed as

Cytochromes cMitochondriaAmino Acid SequenceCytochromes c

Identifiers

PMID38378784
PMCPMC10879542
OpenAlexW4391954034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.