Evidence map›Paper›PMID 38378765›Full record

SynthesisEuropean journal of clinical nutrition2024

Effects of dietary supplements, foods, and dietary patterns in Parkinson's disease: meta-analysis and systematic review of randomized and crossover studies.

Lingyu Wu, Liwen Chu, Yufei Pang, Jinghong Huo, Hongdou Cao, Qi Tian, Qinghan Gao

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingyu WuSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Liwen ChuSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Yufei PangSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Jinghong HuoSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Hongdou CaoSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Qi TianSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Qinghan GaoSchool of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China. gaoqinghan85@126.com.ORCID http://orcid.org/0000-0002-8162-6165

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82060596
6 · The paper itself

Abstract

backgroundDiet significantly impacts Parkinson's disease (PD) with plausible biological hypotheses. Although the thesis has been explored in several human clinical trials, no current meta-analyses or reviews summarize the results. We examined the effect of intervention of dietary supplements, foods, and dietary patterns in treating PD.

methodsWe conducted a meta-analysis and systematic review of randomized and crossover studies published between 1989 and 26 June 2022, searching from PubMed, Embase, Medline, Scopus, Cochrane Library databases, and Chinese databases. Twenty-four studies were included in this review.

resultsThe meta-analysis results show that dietary supplements intervention significantly increased the quantitative insulin sensitivity check index (QUICKI) [MD = 0.02, 95% CI (0.01, 0.02), p < 0.00001]. Dietary supplement intervention does not significantly affect the total Unified Parkinson Disease Rating Scale (UPDRS) score and six-min walk test (6MWT) distance. We did not find evidence that dietary supplements or food intervention may minimize the UPDRS III score. However, systematic review results indicated that the Mediterranean, low-fat, and ketogenic diets significantly reduced the total UPDRS score; low-protein diets meaningfully mitigated motor symptoms.

conclusionsThis meta-analysis result displays that diet and diet supplements had a very modest but statistically significant impact on QUICKI but no effect on motor and non-motor symptoms in PD. The systematic review concludes that dietary patterns intervention may positively attenuate the overall symptoms of PD, including both motor and non-motor symptoms.

Indexed as

Cross-Over StudiesDietary SupplementsParkinson DiseaseDietHumansRandomized Controlled Trials as Topic

Identifiers

PMID38378765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.