Evidence map›Paper›PMID 38378704›Full record

Trial reportNature communications2024

WASH interventions and child diarrhea at the interface of climate and socioeconomic position in Bangladesh.

Pearl Anne Ante-Testard, Francois Rerolle, Anna T Nguyen, Sania Ashraf, Sarker Masud Parvez, Abu Mohammed Naser, Tarik Benmarhnia, Mahbubur Rahman, Stephen P Luby, Jade Benjamin-Chung and 1 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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  10. Biochemistry and biophysics reports · 2025
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  15. Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Pearl Anne Ante-TestardFrancis I. Proctor Foundation and Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA. pearl.ante@ucsf.edu.ORCID 0000-0002-3416-0817
Francois RerolleFrancis I. Proctor Foundation and Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Anna T NguyenDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Sania AshrafEnvironmental Health and WASH, Health System and Population Studies Division, icddr,b, Dhaka, 1212, Bangladesh.
Sarker Masud ParvezEnvironmental Health and WASH, Health System and Population Studies Division, icddr,b, Dhaka, 1212, Bangladesh.
Abu Mohammed NaserDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Tarik BenmarhniaScripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA.
Mahbubur RahmanEnvironmental Health and WASH, Health System and Population Studies Division, icddr,b, Dhaka, 1212, Bangladesh.ORCID 0000-0003-0520-2683
Stephen P LubyDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5385-899X
Jade Benjamin-ChungDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3631-3132
Benjamin F ArnoldFrancis I. Proctor Foundation and Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6105-7295
International Centre for Diarrhoeal Disease Research · BDScripps Institution of Oceanography · USStanford University · USUniversity of California, San Francisco · USChan Zuckerberg Initiative (United States) · USThe University of Queensland · AUUniversity of Memphis · US

Funding

Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settingsR01AI166671 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Benjamin F Arnold · 2022 to 2026
$2.7M
Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health ResearchT32HL151323 · NHLBI · STANFORD UNIVERSITY · PI Michelle Christina Odden, David H Rehkopf · 2020 to 2026
$1.6M
NHLBI NIH HHS T32 HL151323NIAID NIH HHS R01 AI166671
6 · The paper itself

Abstract

Many diarrhea-causing pathogens are climate-sensitive, and populations with the lowest socioeconomic position (SEP) are often most vulnerable to climate-related transmission. Household Water, Sanitation, and Handwashing (WASH) interventions constitute one potential effective strategy to reduce child diarrhea, especially among low-income households. Capitalizing on a cluster randomized trial population (360 clusters, 4941 children with 8440 measurements) in rural Bangladesh, one of the world's most climate-sensitive regions, we show that improved WASH substantially reduces diarrhea risk with largest benefits among children with lowest SEP and during the monsoon season. We extrapolated trial results to rural Bangladesh regions using high-resolution geospatial layers to identify areas most likely to benefit. Scaling up a similar intervention could prevent an estimated 734 (95% CI 385, 1085) cases per 1000 children per month during the seasonal monsoon, with marked regional heterogeneities. Here, we show how to extend large-scale trials to inform WASH strategies among climate-sensitive and low-income populations.

Indexed as

HygieneSanitationBangladeshChildDiarrheaHand DisinfectionHumansRural PopulationSocioeconomic FactorsWaterWater

Identifiers

PMID38378704
PMCPMC10879131
OpenAlexW4391971178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.