ArticleNature communications2024
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- Heparanase-Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity.Journal of extracellular vesicles · 2026Article
- IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself.The Journal of experimental medicine · 2026Article
- CAR Treg therapies for neurodegenerative diseases.iScience · 2026Review
- Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist.Drug delivery · 2025Article
- ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs.Journal of experimental & clinical cancer research : CR · 2025Article
- IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself.bioRxiv : the preprint server for biology · 2025Article
- Hyaluronan Accumulates in Inflamed Lymph Nodes and Promotes B-Cell Activation.Proteoglycan research · 2025Article
- Exploration of biomaterial-tissue integration in heterogeneous microporous annealed particle scaffolds in subcutaneous implants over 12 months.Acta biomaterialia · 2025Article
Corrections and comments
- Update ofFOXP32023
Authors and funding
24 authors at 8 institutions in 4 countries.
Hunter A MartinezDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1129-3382
Ievgen KoliesnikDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1959-7954
Gernot KaberDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6184-5192
Jacqueline K ReidDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Nadine NagyDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2638-2436
Graham BarlowDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9335-5414
Ben A FalkMatrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.
Carlos O MedinaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Aviv HargilDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Svenja ZihslerDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Israel VlodavskyTechnion Integrated Cancer Center, Technion, Haifa, Israel.ORCID 0000-0001-9921-898X
Jin-Ping LiDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Magdiel Pérez-CruzDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Sai-Wen TangDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Everett H MeyerDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Lucile E WrenshallDepartment of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
James D LordTranslational Research Program, Benaroya Research Institute, Seattle, WA, USA.
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9273-0278
Theo D PalmerDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6266-1862
Lawrence SteinmanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2437-2250
Gerald T NepomImmune Tolerance Network, Benaroya Research Institute, Seattle, WA, USA.
Thomas N WightMatrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.
Paul L Bollyky *Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2499-9448
Hedwich F Kuipers *Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. hedwich.kuipers@ucalgary.ca.ORCID 0000-0002-7275-5889
Stanford University · USMatrix Research (United States) · USUniversity of Calgary · CABenaroya Research InstituteImmune Tolerance Network · USTechnion – Israel Institute of Technology · ILUppsala University · SEWright State University · US
Funding
Defining the role of altered cytokine signaling pathways on autoimmunityU01AI101990 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2016
$12.1MStructure-based engineering of immune cytokine signalingR01AI051321 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2002 to 2026
$5.6MSUSCEPTIBILITY GENES IN TYPE I DIABETESR01DK046635 · NIDDK · UNIVERSITY OF VIRGINIA · PI CONCANNON, PATRICK · 1993 to 2013
$5.4MTissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0MLymph Node Extracellular Matrix in Antigen Presentation and Immune RegulationR01DK096087 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$3.4MHLA SUSCEPTIBILITY GENES IN RHEUMATOID ARTHRITIS (RA)R01AR037296 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI NEPOM, GERALD T · 1986 to 2009
$2.9MThe Stanford Clinical Center for the Study of Type 1 Diabetes in Acute PancreatitisU01DK127395 · NIDDK · STANFORD UNIVERSITY · PI Marina Basina, Walter Gwang-Up Park · 2020 to 2026
$2.2MThe Role of Hyaluronan and CD44 in the Pathogenesis of Type 2 DiabetesR01DK116782 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2020 to 2023
$1.6MExtracellular matrix and the regulation of adaptive immune responsesK08DK080178 · NIDDK · UNIVERSITY OF WASHINGTON · PI BOLLYKY, PAUL L · 2007 to 2011
$702kHeparanase and Regulatory T cell Stability and FunctionR21AI133240 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2019
$438kNIAID NIH HHS R01 AI051321NIAID NIH HHS R21 AI133240NIAID NIH HHS U01 AI101984NIAID NIH HHS U01 AI101990NIAMS NIH HHS R01 AR037296NIDDK NIH HHS K08 DK080178NIDDK NIH HHS R01 DK046635NIDDK NIH HHS R01 DK096087NIDDK NIH HHS R01 DK116782NIDDK NIH HHS U01 DK127395
Abstract
Although FOXP3
Indexed as
Encephalomyelitis, Autoimmune, ExperimentalT-Lymphocytes, RegulatoryAnimalsExtracellular MatrixGlucuronidaseHeparanaseHeparan SulfateHumansInterleukin-2MiceGlucuronidaseHeparanaseHeparan SulfateInterleukin-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.