Evidence map›Paper›PMID 38378628›Full record

ArticleeNeuro2024

Demyelination and Na

Jeong Han Lee, Seojin Park, Maria C Perez-Flores, Yingying Chen, Mincheol Kang, Jinsil Choi, Lauren Levine, Michael Anne Gratton, Jie Zhao, Lucia Notterpek and 1 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jeong Han LeeDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Seojin ParkDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Maria C Perez-FloresDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Yingying ChenDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Mincheol KangDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Jinsil ChoiDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Lauren LevineProgram in Audiology and Communication Sciences, Washington University, St. Louis 63110, Missouri.
Michael Anne GrattonBoys Town National Research Hospital, Omaha 68131, Nebraska.
Jie ZhaoDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada.
Lucia NotterpekDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada enyamoah@gmail.com lnotterpek@unr.edu.ORCID https://orcid.org/0000-0002-3571-8798
Ebenezer N YamoahDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Reno 89557, Nevada enyamoah@gmail.com lnotterpek@unr.edu.ORCID https://orcid.org/0000-0002-9797-085X
University of Nevada, Reno · USBoys Town National Research Hospital · USWashington University in St. Louis · US

Funding

Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC016099
6 · The paper itself

Abstract

Altered expression of peripheral myelin protein 22 (PMP22) results in demyelinating peripheral neuropathy. PMP22 exhibits a highly restricted tissue distribution with marked expression in the myelinating Schwann cells of peripheral nerves. Auditory and vestibular Schwann cells and the afferent neurons also express PMP22, suggesting a unique role in hearing and balancing. Indeed, neuropathic patients diagnosed with PMP22-linked hereditary neuropathies often present with auditory and balance deficits, an understudied clinical complication. To investigate the mechanism by which abnormal expression of PMP22 may cause auditory and vestibular deficits, we studied gene-targeted

Indexed as

Demyelinating DiseasesMyelin ProteinsAnimalsHumansMiceMice, KnockoutMyelin SheathSchwann CellsMyelin ProteinsPMP22 protein, humanPmp22 protein, mousedemylinationhearing lossneuropathyPMP22sodium channelsvestibular hypofunction

Identifiers

PMID38378628
PMCPMC11059428
OpenAlexW4391973249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.