Evidence map›Paper›PMID 38378084›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2024

Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease.

Hao Huang, Md Golam Sharoar, Joseph Pathoulas, Liangliang Fan, Wanxia He, Rong Xiang, Riqiang Yan

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hao HuangDepartment of Nephrology, Xiangya Hospital and National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China; Department of Neuroscience, University of Connecticut Health, Farmington, CT, USA; Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China; Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, China. Electronic address: xyskhuanghao@csu.edu.cn.
Md Golam SharoarDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA; Alzheimer's Disease Research Program, Corewell Health Research Institute, Oakland University William Beaumont School of Medicine, Corewell Health East, Royal Oak, MI 48073, USA.
Joseph PathoulasDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Liangliang FanDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, China.
Wanxia HeDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA.
Rong XiangDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, China; Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, China. Electronic address: shirlesmile@csu.edu.cn.
Riqiang YanDepartment of Neuroscience, University of Connecticut Health, Farmington, CT, USA. Electronic address: riyan@uchc.edu.
Central South University · CNUConn Health · USOakland University · US

Funding

Roles of reticulon proteins in neurodegenerative disordersR01AG025493 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2005 to 2024
$5.9M
Roles of reticulon proteins in neurodegenerative disordersRF1AG025493 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YAN, RIQIANG · 2020 to 2020
$3.0M
NIA NIH HHS R01 AG025493NIA NIH HHS RF1 AG025493
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the formation β-amyloid (Aβ) deposited neuritic plaques. Recent evidence suggests that abnormal lipid metabolism and accumulation could serve as biomarkers for neurodegenerative diseases, including AD. Tubular endoplasmic reticulum protein, reticulon 3 (RTN3), plays a crucial role in the development of neuritic plaque and lipid metabolism in AD brains. In present study, we sought to investigate a potential association between neutral lipid accumulation and AD pathology. BODIPY 500/510 dye was used to label neutral lipid surrounding Aβ plaques in APP

Indexed as

Alzheimer DiseaseAnimalsHumansLipidsMiceMice, TransgenicNerve Tissue ProteinsNeuritesPlaque, AmyloidLipidsNerve Tissue ProteinsAlzheimer's diseaseAutophagic vacuolesDystrophic neuritesNeutral lipidsRTN3

Identifiers

PMID38378084
PMCPMC10999334
OpenAlexW4391912834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.