Evidence map›Paper›PMID 38378030›Full record

ArticleRadiology and oncology2024

The influence of cytotoxic drugs on the immunophenotype of blast cells in paediatric B precursor acute lymphoblastic leukaemia.

Tomaz Prelog, Simon Bucek, Andreja Brozic, Jakob Peterlin, Marko Kavcic, Masa Omerzel, Bostjan Markelc, Tanja Jesenko, Veronika Kloboves Prevodnik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology and oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tomaz PrelogDepartment of Haemato-Oncology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Simon BucekDepartment of Cytopathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Andreja BrozicDepartment of Cytopathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Jakob PeterlinInstitute for Biostatistics and Medical Informatics, University of Ljubljana, Ljubljana, Slovenia.
Marko KavcicDepartment of Haemato-Oncology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Masa OmerzelDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Bostjan MarkelcDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Tanja JesenkoFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Veronika Kloboves PrevodnikFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Institute of Oncology Ljubljana · SIUniversity of Ljubljana · SILjubljana University Medical Centre · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFlow cytometry plays is important in the diagnosis of acute lymphoblastic leukaemia (ALL) and when antigen-specific immunotherapy is indicated. We have investigated the effects of prednisolone, vincristine, daunorubicin, asparaginase and methotrexate on the antigen expression on blast cells that could influence the planning of antigen-specific therapy as well as risk-based treatment assignment. PATIENTS AND

methodsPatients aged ≤ 17 years with

resultsCytotoxic drugs caused dose-dependent or dose-independent modulation of antigen expression. Daunorubicin caused a dose-dependent down-modulation of CD10, CD19, CD34, CD45 and CD58 and an up-modulation of CD137. Vincristine caused a dose-dependent down-modulation of CD19 and CD58 and an up-modulation of CD45. Daunorubicin also caused dose-independent down-modulation of CD27 and prednisolone down-modulation of CD10, CD19, CD27, CD34 and CD58. Down-modulation of CD20 was detected only in relation to the specific dose of daunorubicin.

conclusionsThe results of the study have shown that cytotoxic drugs can alter the expression of antigens that are important for immunotherapy. Importantly, daunorubicin, prednisolone and vincristine caused down-modulation of CD19 and CD58, suggesting that these drugs are better avoided during bridging therapy prior to bispecific antibodies or CAR-T cell therapy. In addition, immunophenotypic changes on blast cells induced by different drugs could also influence risk-based treatment assignment.

Indexed as

Antineoplastic AgentsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaChildDaunorubicinHumansPrednisoloneVincristineAntineoplastic AgentsDaunorubicinPrednisoloneVincristinechemotherapyimmunophenotypic changesimmunotherapypaediatric B-ALL

Identifiers

PMID38378030
PMCPMC10878768
OpenAlexW4391955975

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.