Evidence map›Paper›PMID 38377945›Full record

ArticleCancer epidemiology2024

BMI and breast cancer risk around age at menopause.

Ann Von Holle, Hans-Olov Adami, Laura Baglietto, Amy Berrington de Gonzalez, Kimberly A Bertrand, William Blot, Yu Chen, Jessica Clague DeHart, Laure Dossus, A Heather Eliassen and 36 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Age-Related Trends in Breast Cancer Incidence.International journal of breast cancer · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 14 countries.

Ann Von HolleBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Hans-Olov AdamiClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinksa Institutet, Stockholm, Sweden.
Laura BagliettoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Amy Berrington de GonzalezDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Kimberly A BertrandSlone Epidemiology Center, Boston University, Boston, MA, USA.
William BlotVanderbilt University Medical Center, Nashville, TN, USA.
Yu ChenDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Jessica Clague DeHartSchool of Community and Global Health, Claremont Graduate University, Claremont, CA, USA.
Laure DossusNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Agnes FournierCentre for Research in Epidemiology and Statistics, Paris, France.
Montse Garcia-ClosasDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Graham GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Marcela GuevaraInstituto de Salud Pública y Laboral de Navarra, Pamplona, Spain.
Susan E HankinsonDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
Alicia HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Corinne E JoshuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
Victoria A KirshOntario Institute for Cancer Research, Toronto, ON, Canada.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore.
Martha S LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Hannah Lui ParkDepartment of Pathology and Laboratory Medicine, Department of Epidemiology, UC Irvine School of Medicine, Irvine, CA, USA.
Giovanna MasalaInstitute for the Study and Prevention of Cancer, Florence, Italy.
Lene MellemkjaerDiet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Julie R PalmerSlone Epidemiology Center, Boston University, Boston, MA, USA.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Thomas E RohanAlbert Einstein College of Medicine, Bronx, NY, USA.
Martha J ShrubsoleVanderbilt University Medical Center, Nashville, TN, USA.
Malin SundDepartment of Surgical and perioperative Sciences/Surgery, Umea University, Sweden.
Rulla TamimiDepartment of Population Health Sciences, Weill Cornell Medical College, NY, USA.
Sandar Tin TinCancer Epidemiology Unit, Oxford Population Health, University of Oxford, United Kingdom.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Roel Ch VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jian-Min YuanDivision of Cancer Control and Population Science, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, PA, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Anne Zeleniuch-JacquotteDepartment of Population Health, NYU Grossman School of Medicine, NY, USA.
Hazel B NicholsDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
Minouk J SchoemakerReal World Solutions, IQVIA, the Netherlands.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: weinberg@niehs.nih.gov.
Institute of Cancer Research · GBNational Institute of Environmental Health Sciences · USBoston University · USCancer Council Victoria · AUCentre international de recherche sur le cancer · FRImperial College London · GBJohns Hopkins University · USNational Cancer Institute · USNew York University · USVanderbilt University Medical Center · USAgency for Science, Technology and Research · SGAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USCancer Research UK Oxford Centre · GBClaremont Graduate University · USCornell University · USDanish Cancer Society · DKGerman Cancer Research Center · DEHarvard University · USInstituto de Salud Pública de Navarra · ES

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Studies of Populations Exposed to Occupational Sources of RadiationZIACP010133 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2009 to 2025
$34.2M
A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
The Two Sister StudyZIAES102245 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2009 to 2025
$8.6M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
Statistical Methods In Epidemiology--generalZIAES040006 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2009 to 2025
$4.5M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Applications of methods in collaborative scienceZIAES103086 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2012 to 2025
$986k
Cancer Research UK 29017Intramural NIH HHS Z01 ES040006Intramural NIH HHS Z01 ES044005Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES103086NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS U01 CA164974NCI NIH HHS UM1 CA182876NIEHS NIH HHS P30 ES010126World Health Organization 001
6 · The paper itself

Abstract

backgroundA high body mass index (BMI, kg/m

methodsWe examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first. Analyses included 609,880 women in 16 prospective studies, including 9956 who developed breast cancer before age 55. We fitted three BMI hazard ratio (HR) models over age-time: constant, linear, or nonlinear (via splines), applying piecewise exponential additive mixed models, with age as the primary time scale. We divided person-time into four strata: premenopause; postmenopause due to natural menopause; postmenopause because of interventional loss of ovarian function (bilateral oophorectomy (BO) or chemotherapy); postmenopause due to hysterectomy without BO. Sensitivity analyses included stratifying by BMI in young adulthood, or excluding women using menopausal hormone therapy.

resultsThe constant BMI HR model provided the best fit for all four menopausal status groups. Under this model, the estimated association between a five-unit increment in BMI and breast cancer risk was HR=0.87 (95% CI: 0.85, 0.89) before menopause, HR=1.00 (95% CI: 0.96, 1.04) after natural menopause, HR=0.99 (95% CI: 0.93, 1.05) after interventional loss of ovarian function, and HR=0.88 (95% CI: 0.76, 1.02) after hysterectomy without BO.

conclusionThe BMI breast cancer HRs remained less than or near one during the 45-55 year age range indicating that the transition to a positive association between BMI and risk occurs after age 55.

Indexed as

Breast NeoplasmsMenopauseAdultBody Mass IndexFemaleHumansMiddle AgedPremenopauseProspective StudiesRisk FactorsYoung AdultBody mass indexBreast neoplasmsMiddle agedPostmenopausePremenopause

Identifiers

PMID38377945
PMCPMC10942753
OpenAlexW4391939527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.