Evidence map›Paper›PMID 38377884›Full record

ReviewCurrent opinion in biotechnology2024

Bridging the gender gap in autoimmunity with T-cell-targeted biomaterials.

Aida López Ruiz, Eric D Slaughter, April M Kloxin, Catherine A Fromen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aida López RuizChemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States.
Eric D SlaughterChemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States.
April M KloxinChemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States; Material Science and Engineering, University of Delaware, Newark, DE, United States. Electronic address: akloxin@udel.edu.
Catherine A FromenChemical and Biomolecular Engineering, University of Delaware, Newark, DE, United States. Electronic address: cfromen@udel.edu.
University of Delaware · US

Funding

Multiscale considerations for immune engineering at mucosal interfacesR35GM142866 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine A Fromen · 2021 to 2026
$2.4M
Unraveling fibrosis with dynamic microenvironments and molecular toolsDP2HL152424 · NHLBI · UNIVERSITY OF DELAWARE · PI KLOXIN, APRIL M · 2019 to 2019
$2.4M
NHLBI NIH HHS DP2 HL152424NIGMS NIH HHS R35 GM142866
6 · The paper itself

Abstract

Autoimmune diseases are caused by malfunctions of the immune system and generally impact women at twice the frequency of men. Many of the most serious autoimmune diseases are accompanied by a dysregulation of T-cell phenotype, both regarding the ratio of CD4+ to CD8+ T-cells and proinflammatory versus regulatory phenotypes. Biomaterials, in the form of particles and hydrogels, have shown promise in ameliorating this dysregulation both in vivo and ex vivo. In this review, we explore the role of T-cells in autoimmune diseases, particularly those with high incidence rates in women, and evaluate the promise and efficacy of innovative biomaterial-based approaches for targeting T-cells.

Indexed as

Autoimmune DiseasesAutoimmunityCD8-Positive T-LymphocytesFemaleHumansMalePhenotypeSex Factors

Identifiers

PMID38377884
PMCPMC11578274
OpenAlexW4391931021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.