Evidence map›Paper›PMID 38377674›Full record

ArticleACS chemical neuroscience2024

Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition.

František Sedlák, Aleš Kvasnička, Barbora Marešová, Radana Brumarová, Dana Dobešová, Kateřina Dostálová, Karolína Šrámková, Martin Pehr, Pavel Šácha, David Friedecký and 1 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

František SedlákInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
Aleš KvasničkaLaboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníku° 248/7, Olomouc 779 00, Czechia.ORCID 0000-0001-5973-316X
Barbora MarešováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
Radana BrumarováLaboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníku° 248/7, Olomouc 779 00, Czechia.
Dana DobešováLaboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníku° 248/7, Olomouc 779 00, Czechia.
Kateřina DostálováLaboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníku° 248/7, Olomouc 779 00, Czechia.
Karolína ŠrámkováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
Martin PehrInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
Pavel ŠáchaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
David FriedeckýLaboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Palacký University Olomouc, Zdravotníku° 248/7, Olomouc 779 00, Czechia.ORCID 0000-0002-3448-9073
Jan KonvalinkaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6 166 10, Czechia.
University Hospital Olomouc · CZCharles University · CZCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutamate carboxypeptidase II (GCPII, also known as PSMA or FOLH1) is responsible for the cleavage of

Indexed as

Glutamate Carboxypeptidase IILipidomicsMetabolomicsAnimalsAntigens, SurfaceBrainDipeptidesGlutamic AcidLipidsMiceAntigens, SurfaceDipeptidesFolh1 protein, mouseGlutamate Carboxypeptidase IIGlutamic Acidisospaglumic acidLipidsFOLH1folyl-poly-γ-glutamyl hydrolase Iglutamate carboxypeptidase IIlipidomicsmetabolomicsN-acetyl-aspartyl-glutamate

Identifiers

PMID38377674
PMCPMC10995945
OpenAlexW4391951031

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.