ArticleACS synthetic biology2024
LanTERN: A Fluorescent Sensor That Specifically Responds to Lanthanides.
Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Uncapping energy transfer pathways in metal-organic frameworks through heterogeneous structures.Nature communications · 2025Article
- Harnessing Dynamic Supramolecular Interactions for Lanthanide Detection via Computational Pattern Recognition of Magnetic Resonance Fingerprints.Journal of the American Chemical Society · 2025Article
- Lanthanide-Controlled Protein Switches: Development and In Vitro and In Vivo Applications.Angewandte Chemie (International ed. in English) · 2025Article
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
- Rare earth elements in biology: From biochemical curiosity to solutions for extractive industries.Microbial biotechnology · 2024Review
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Authors and funding
6 authors.
Funding
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Abstract
Lanthanides, a series of 15 f-block elements, are crucial in modern technology, and their purification by conventional chemical means comes at a significant environmental cost. Synthetic biology offers promising solutions. However, progress in developing synthetic biology approaches is bottlenecked because it is challenging to measure lanthanide binding with current biochemical tools. Here we introduce LanTERN, a lanthanide-responsive fluorescent protein. LanTERN was designed based on GCaMP, a genetically encoded calcium indicator that couples the ion binding of four EF hand motifs to increased GFP fluorescence. We engineered eight mutations across the parent construct's four EF hand motifs to switch specificity from calcium to lanthanides. The resulting protein, LanTERN, directly converts the binding of 10 measured lanthanides to 14-fold or greater increased fluorescence. LanTERN development opens new avenues for creating improved lanthanide-binding proteins and biosensing systems.
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