Evidence map›Paper›PMID 38377422›Full record

ArticleBrain, behavior, & immunity - health2020

Acute exercise decreases vaccine reactions following influenza vaccination among older adults.

Erika Bohn-Goldbaum, April Pascoe, Maria Fiatarone Singh, Nalin Singh, Jen Kok, Dominic E Dwyer, Elizabeth Mathieson, Robert Booy, Kate M Edwards

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  3. Review
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  11. Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19.Perspectives on psychological science : a journal of the Association for Psychological Science · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Erika Bohn-GoldbaumThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia.
April PascoeThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia.
Maria Fiatarone SinghThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia.
Nalin SinghThe Centre for STRONG Medicine, Pymble, NSW, Australia.
Jen KokInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, Australia.
Dominic E DwyerInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, Australia.
Elizabeth MathiesonThe Centre for STRONG Medicine, Balmain Hospital, Balmain, NSW, Australia.
Robert BooyThe University of Sydney, National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, Australia.
Kate M EdwardsThe University of Sydney, Faculty of Health Sciences and Charles Perkins Centre, Sydney, Australia.
The University of Sydney · AUTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exercise on the acute and longer-term responses to influenza vaccination among healthy older adults. Forty-six participants (47.8% male, mean 73.4 ± 6.6 years) were randomised to perform one 45-min moderate-intensity resistance exercise session or sit quietly prior to the receipt of influenza vaccination. Acute exercise reduced vaccine reactions but had no effect on either antibody responses or development of influenza-like symptoms during six months of follow-up. Psychosocial and behavioural characteristics were examined for potential associations with the responses to vaccination. Participants (n = 36) vaccinated in the previous year had higher baseline antibody titres but not follow-up titres nor more frequent experience of influenza-like symptoms over 6 months compared to those unvaccinated in the previous year. These findings provide further support for the ability of acute exercise to reduce vaccine reactions and suggest risk factors for vaccine responses for future exploration.

Indexed as

Acute exerciseImmune functionOlder adultsVaccination

Identifiers

PMID38377422
PMCPMC8474530
OpenAlexW2990474300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.