ArticleBrain, behavior, & immunity - health2020
Impact of physical activity on monocyte subset CCR2 expression and macrophage polarization following moderate intensity exercise.
Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Influence of resistance exercise on monocyte subtypes and intracellular immune markers in trained postmenopausal women.European journal of applied physiology · 2026Trial
- CCR2Frontiers in pharmacology · 2026Article
- 4-week aerobic exercise training regulates systemic macrophage polarization in obese mice.PeerJ · 2026Article
- Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis.Cardiovascular research · 2025Review
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
- The Effect of Exercise on Immune Response in Population with Increased Risk Factors for Cardiovascular Disease: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- LPS-induced whole-blood cytokine production and depressive symptoms in dementia spousal caregivers: The moderating effect of childhood trauma.Psychoneuroendocrinology · 2024Article
- Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024Review
- Do Men and Women Differ in Hematological Adaptations to 24 Weeks of Crossfit® Training?Journal of human kinetics · 2024Article
- High-intensity training on CREB activation for improving brain health: a narrative review of possible molecular talks.Frontiers in endocrinology · 2024Review
- Adipose inflammation: South Asian ethnicity and central obesity are independently associated with higher immune cell recruitment to adipose-specific media: A pilot study in men.Physiological reports · 2023Article
- Circulating Levels of IL-8 and MCP-1 in Healthy Adults: Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism.International journal of molecular sciences · 2023Article
- Potential Local Mechanisms for Exercise-Induced Hypoalgesia in Response to Blood Flow Restriction Training.Cureus · 2023Review
- Neighborhood socioeconomic deprivation and individual-level socioeconomic status are associated with dopamine-mediated changes to monocyte subset CCR2 expression via a cAMP-dependent pathway.Brain, behavior, & immunity - health · 2023Article
- Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals.Physiological reports · 2023Article
- The Multifaceted Roles of Macrophages in NAFLD Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2023Review
- Sports Participation and Anti-Epidemic: Empirical Evidence on the Influence of Regular Physical Activity on the COVID-19 Pandemic in Mainland China.International journal of environmental research and public health · 2022Article
- Are Sports Champions Also Anti-Epidemic Heroes? Quantitative Research on the Influence of Sports Champions' Demonstration Effect on the COVID-19 Epidemic in China.International journal of environmental research and public health · 2022Article
- The effects of the COVID-19 pandemic on the physical activity of the Thai population: Evidence from Thailand's Surveillance on Physical Activity 2020.Journal of sport and health science · 2021Article
- Prevalence of sufficient MVPA among Thai adults: pooled panel data analysis from Thailand's surveillance on physical activity 2012-2019.BMC public health · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) is an immune-mediated disease in which CCR2 attracts classical, intermediate, and non-classical monocytes to the arterial intima where they differentiate to macrophages. Balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages contributes to CAD prevention. Moderate to vigorous intensity physical activity (MVPA) elicits an immune response and reduces the incidence of CAD, however, the impact of prior MVPA on monocyte subset CCR2 expression and macrophage polarization following acute exercise is unknown. Purpose: To determine the impact of physical activity status on monocyte subset CCR2 surface expression and macrophage polarization in response to an acute bout of moderate intensity cycle ergometry. Methods: 24 healthy women and men (12 high physically active [HIACT]: ≥1500 METmin/wk MVPA & 12 low physically active [LOACT]: <600 METmin/wk MVPA) underwent an acute moderate intensity (60% VO Results: Intermediate monocyte CCR2 decreased in response to exercise in the HIACT group (PRE: 11409.0 ± 1084.0 vs. POST: 9524.3 ± 1062.4; p = 0.034). Macrophage CD206 was lower in the LOACT compared to the HIACT group at 1H (HIACT: 67.2 ± 5.6 vs. LOACT: 50.1 ± 5.2%; p = 0.040). Macrophage CD206 at 1H was associated with both PRE (r = 0.446, p = 0.043) and POST (r = 0.464, p = 0.034) non-classical monocyte CCR2. Conclusion: These data suggest that regular moderate to vigorous physical activity positively impacts both monocytes and macrophages following acute moderate intensity exercise and that this impact may contribute to the prevention of coronary artery disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.