Evidence map›Paper›PMID 38377384›Full record

ArticleACS chemical biology2024

Antibacterial Marinopyrroles and Pseudilins Act as Protonophores.

Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Identification of Natural-Product Inhibitors of the 2ACS medicinal chemistry letters · 2026
    Article
  3. Article
  4. Review
  5. Marine natural products.Natural product reports · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Expanded Gram-Negative Activity of Marinopyrrole A.Pathogens (Basel, Switzerland) · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Gabriel Castro-FalcónCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, California 92093, United States.
Jan StraetenerDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Jan BornikoelDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Daniela ReimerCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, California 92093, United States.
Trevor N PurdyCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, California 92093, United States.
Anne BerscheidDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0003-1585-8715
Florence M SchemppCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, California 92093, United States.
Dennis Y LiuDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0003-1818-4971
Heike Brötz-OesterheltDepartment of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0001-9364-1832
Chambers C HughesCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, California 92093, United States.ORCID 0000-0002-7000-6438
Scripps Institution of Oceanography · USMicrobial Chemistry Research Foundation · JPSimon Fraser University · CA

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Elucidating the mechanism of action (MoA) of antibacterial natural products is crucial to evaluating their potential as novel antibiotics. Marinopyrroles, pentachloropseudilin, and pentabromopseudilin are densely halogenated, hybrid pyrrole-phenol natural products with potent activity against Gram-positive bacterial pathogens like

Indexed as

Biological ProductsHydrocarbons, ChlorinatedAnimalsAnti-Bacterial AgentsMammalsMicrobial Sensitivity TestsPyrrolesAnti-Bacterial AgentsBiological ProductsHydrocarbons, ChlorinatedpentachloropseudilinPyrroles

Identifiers

PMID38377384
PMCPMC10949930
OpenAlexW4391951899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.