Evidence map›Paper›PMID 38376628›Full record

Trial reportClinical oral investigations2024

Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial.

Mai Adnan Gaizeh Al-Hallak, Karim Chalhoub, Jamileh Ali Hsaian, Abeer Ahmad Aljoujou

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mai Adnan Gaizeh Al-HallakFaculty of Dentistry, Oral Medicine Department, Oral Medicine, Damascus University, Damascus, Syria. maighallak@gmail.com.ORCID http://orcid.org/0009-0003-3008-3492
Karim ChalhoubFaculty of Dentistry, Syrian Private University, Damascus, Syria.
Jamileh Ali HsaianDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus, Syria.ORCID http://orcid.org/0009-0007-6474-8244
Abeer Ahmad AljoujouFaculty of Dentistry, Oral Medicine Department, Oral Medicine, Damascus University, Damascus, Syria.ORCID http://orcid.org/0000-0001-8606-3122

Funding

Damascus University 501100020595
6 · The paper itself

Abstract

objectivesThis study is aimed at assessing the therapeutic efficacy of photobiomodulation therapy (PBMT) for the management of recurrent herpes labialis (RHL) by evaluating both pain and clinical recovery. MATERIAL AND

methodsA randomized, double-blind, controlled trial was conducted on 40 patients with RHL, and they were randomly divided into two groups, where 20 patients received treatment with PBMT (650 nm, 100 mW, 4.7 J/cm

resultsThe pain level in the control group was significantly higher than that in the PBMT group after the second application of the laser, while the differences were not significant between the two groups at other times. The pain in the PBMT group disappeared faster than that in the control group, but the difference was not significant in terms of clinical recovery.

conclusionsPhotobiomodulation therapy of herpes labialis reduced pain significantly faster than acyclovir, but there was no difference in healing time between the groups in light of the parameters used in this study. CLINICAL RELEVANCE: PBMT is a promising treatment that may be an effective alternative to acyclovir in the management of recurrent herpes labialis. TRIAL REGISTRATION ISRCTN: com ID: ISRCTN87606522.

Indexed as

Herpes LabialisLow-Level Light TherapyAcyclovirHumansPainWound HealingAcyclovirAcyclovirDiode laserHerpes simplex virusPhotobiomodulation therapyRecurrent herpes labial

Identifiers

PMID38376628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.