Evidence map›Paper›PMID 38376554›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Brain and spine malformations and neurodevelopmental disorders in a cohort of children with CAKUT.

Silvia Boeri, Monica Bodria, Rosa Maria Ammendola, Thea Giacomini, Domenico Tortora, Lino Nobili, Michela Malacarne, Andrea Rossi, Enrico Verrina, Giorgio Piaggio and 2 more

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silvia BoeriDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Monica BodriaUnit of Nephrology and Kidney Transplant, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Rosa Maria AmmendolaRadiology Unit, Azienda Socio-Sanitaria Territoriale Della Brianza, Monza, Italy.
Thea GiacominiDepartment of Mental Health and Addiction, Azienda Sanitaria Locale 3, Genoa, Italy.
Domenico TortoraChild Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Largo G Gaslini, 5, 16147, Genova, Italy.
Lino NobiliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Michela MalacarneHuman Genetics Laboratory, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Andrea RossiDepartment of Mental Health and Addiction, Azienda Sanitaria Locale 3, Genoa, Italy.
Enrico VerrinaUnit of Nephrology and Kidney Transplant, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Giorgio PiaggioUnit of Nephrology and Kidney Transplant, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Maria Margherita MancardiChild Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Largo G Gaslini, 5, 16147, Genova, Italy. margheritamancardi@gaslini.org.ORCID 0000-0001-5122-4029
Mariasavina SeverinoDepartment of Mental Health and Addiction, Azienda Sanitaria Locale 3, Genoa, Italy.

Funding

Ministero della Salute MSALRF DEL68/21
6 · The paper itself

Abstract

backgroundCongenital anomalies of the kidney and urinary tract (CAKUT) represent 20-30% of all birth defects and are often associated with extra-renal malformations. We investigated the frequency of brain/spine malformations and neurological features in children with CAKUT.

methodsWe reviewed the clinico-radiological and genetic data of 199 out of 1,165 children with CAKUT evaluated from 2006 to 2023 (99 males, mean age at MRI 6.4 years) who underwent brain and/or spine MRI. Patients were grouped according to the type of CAKUT (CAKUT-K involving the kidney and CAKUT-H involving the inferior urinary tract). Group comparisons were performed using χ

resultsBrain/spine malformations were observed in 101/199 subjects (50.7%), 8.6% (101/1165) of our CAKUT population, including midbrain-hindbrain anomalies (40/158, 25.3%), commissural malformations (36/158, 22.7%), malformation of cortical development (23/158, 14.5%), Chiari I anomaly (12/199, 6%), cranio-cervical junction malformations (12/199, 6%), vertebral defects (46/94, 48.9%), caudal regression syndrome (29/94, 30.8%), and other spinal dysraphisms (13/94, 13.8%). Brain/spine malformations were more frequent in the CAKUT-K group (62.4%, p < 0.001). Sixty-two subjects (62/199, 31.2%) had developmental delay/intellectual disability. Neurological examination was abnormal in 40/199 (20.1%). Seizures and/or electroencephalographic anomalies were reported in 28/199 (14%) and behavior problems in 19/199 subjects (9%). Developmental delay/intellectual disability was more frequent in kidney dysplasia (65.2%) and agenesis (40.7%) (p = 0.001).

conclusionsWe report a relative high frequency of brain/spine malformations and neurodevelopmental disorders in children with CAKUT who underwent MRI examinations in a tertiary referral center, widening the spectrum of anomalies associated with this condition.

Indexed as

BrainMagnetic Resonance ImagingNeurodevelopmental DisordersSpineUrogenital AbnormalitiesAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesVesico-Ureteral RefluxBrain and spinal malformationsBrain and spinal MRICongenital anomalies of the kidney and urinary tract (CAKUT)Genetic syndromesNeurodevelopmental disorders

Identifiers

PMID38376554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.